02 February 2019 : Animal Research
Atorvastatin Protects Against Cerebral Aneurysmal Degenerative Pathology by Promoting Endothelial Progenitor Cells (EPC) Mobilization and Attenuating Vascular Deterioration in a Rat Model
Huijie Wei1ACEFG*, Mengchen Yang1C, Kai Yu1E, Wang Dong1CE, Wang Liang12C, Zengguang Wang1ACE, Rongcai Jiang1BEG, Jianning Zhang1ACEGDOI: 10.12659/MSM.915005
Med Sci Monit 2019; 25:928-936
Abstract
BACKGROUND: Endothelial injury is the early pathological change of cerebral aneurysm (CA) formation. In addition to its lipid-lowering activity, atorvastatin (ATR) also reportedly promotes vascular repair via mobilizing endothelial progenitor cells (EPC). Here, we investigated the influence of ATR on vascular worsening after CA induction in rats.
MATERIAL AND METHODS: Adult male Sprague-Dawley rats were randomly assigned to 3 groups: a control (CTR) group, a CA group, and a CA+ATR treatment group. Circulating EPC level and hematological and lipid profiles were measured 3 months after CA induction. Verhoeff-Van Gieson staining and transmission electron microscopy were performed to assess pathological changes in the artery wall. RT-PCR was also performed to evaluate the expression of inflammation-related genes in the aneurysmal wall.
RESULTS: ATR significantly restored the impaired level of circulating EPC without changing hematological and lipid profiles 3 months after CA induction. ATR markedly inhibited endothelial injury, media thinning, and CA enlargement, accompanied by reduced vascular inflammation.
CONCLUSIONS: Our preliminary results demonstrate that the mobilization of EPC and improvement of endothelial function by ATR contribute to the prevention of cerebral aneurysm. Further studies are warranted to investigate the detailed mechanism.
Keywords: endothelial cells, intracranial aneurysm, Neovascularization, Pathologic, Pathology, Molecular, atorvastatin, endothelial progenitor cells, Hematopoietic Stem Cell Mobilization, Protective Agents
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