H-Index
34
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
call: +1.631.629.4327
Mon-Fri 10 am - 2 pm EST

Logo



eISSN: 2329-0358

Get your full text copy in PDF

Correlation Between Stem and Progenitor Cells Number and Immune Response in Patients After Allogeneic Kidney Transplant

Jerzy Sieńko, Maciej Kotowski, Edyta Paczkowska, Anna Sobuś, Karol Tejchman, Jarosław Piątek, Ewa Pilichowska, Karolina Kędzierska-Kapuza, Marek Ostrowski

(Department of General Surgery and Transplantation, Pomeranian Medical University, Szczecin, Poland)

Ann Transplant 2018; 23:874-878

DOI: 10.12659/AOT.912686


BACKGROUND: Stem and progenitor cells are of great interest in all medical procedures involving tissue regeneration. There is a consensus that the use of stem cells after solid organ transplantation may play a role in tissue repair and in immunosuppression. The aim of this study was to determine possible relations between stem cell count and the immune response in a group of patients after kidney transplantation.
MATERIAL AND METHODS: The study was conducted on a group of 100 patients who underwent kidney transplantation. The following phenotypic markers of the studied cell subpopulations were adopted: Treg cells (CD3+CD4+CD25high), circulating hematopoietic cells (CD34+CD133+CD45+CD38–), and non-hematopoietic cells (Lin–CXCR4+CD133–CD45–). Cell subpopulations were assessed using LSRII flow cytometer (BD Biosciences, San Jose, CA, USA).
RESULTS: Positive correlation was observed between non-hematopoietic stem cells percentage and recipient’s platelets count (P=0.04). Moreover, a higher percentage of non-hematopoietic cells was accompanied by lower numbers of B lymphocytes (P=0.03) and Treg cells (P=0.02).
CONCLUSIONS: Our study revealed significant associations between the intensity of ongoing immune response processes and tissue damage, and the release of stem and progenitor cells into circulation. These findings suggest their role in the stimulation of protective processes in terms of graft regeneration.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree