16 November 2018 : Original article
Results of Adult Living Donor Liver Transplantation with Sixth-Decade Donors: A Propensity Score Matching Study in a High-Volume Institution
Seok-Hwan Kim12ABCDEF, Gil-Chun Park1ABCDE, Shin Hwang1ABCDEF*, Chul-Soo Ahn1BCD, Ki-Hum Kim1BCD, Deok-Bog Moon1BCD, Tae-Yong Ha1BCD, Gi-Won Song1BCD, Dong-Hwan Jung1BCD, Hwi-Dong Cho1BCD, Jae-Hyun Kwon1BCD, Yong-Kyu Jung1BCD, Su-Min Ha1BCD, Sang-Hyun Kang1BCD, Sung-Gyu Lee1BCDDOI: 10.12659/AOT.911550
Ann Transplant 2018; 23:802-807
Abstract
BACKGROUND: We assessed the prognostic impact of donor age on the outcome of adult living donor liver transplantation (LDLT).
MATERIAL AND METHODS: The study population comprised adult donor and recipients of right lobe grafts for LDLT performed from January 2005 to December 2016. There were 35 living donors aged ≥50 years (old-age donor group). As a control group, donors in their 20s (young-age donor group) were selected after one-to-one propensity score matching based on sex, model for end-stage liver disease (MELD) score, and primary diagnosis.
RESULTS: Donor age was 52.5±1.5 years versus 25.4±3.1 years in the old- and young-age donor groups, respectively. Remnant volumes of the 2 groups were 38.9±3.0% versus 38.1±2.9%, respectively (p=0.98). One-month regeneration rate of the remnant liver was 101.1±10.6% versus 104.5±11.8%, respectively (p=0.08), and there was no significant difference in the incidences of donor complications. Mean MELD score was 15 versus 14, respectively (p=0.82). Graft-to-recipient weight ratio was 1.02±0.43 versus 0.91±0.63, respectively (p=0.28). In the recipients, biliary complication occurred in 11.4% versus 8.6%, respectively (p=0.12), and there was no difference in 5-year survival rates of both groups (p=0.15). The 1-week and 1-month regeneration rates of the remnant left liver were 71.6±9.9% and 100.1±10.6% in the old-age group, respectively, whereas those were 80.2±12.1% and 104.5±11.8% in the young-age group, respectively (p=0.08).
CONCLUSIONS: Right lobe grafts from donors aged ≥50 years showed the usual recovery of graft function but rather delayed liver regeneration. Thus, old-aged donors should be selected prudently after consideration of hepatic resection rate, graft size, and hepatic steatosis.
Keywords: Donor Selection, Liver Cirrhosis, Living Donors
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