Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

14 July 2017 : Original article  

Serum Uric Acid and Arterial Function After Renal Transplantation

Frederic Bauer12ABCDEF*, Nikolaos Pagonas12ABD, Felix S. Seibert12BD, Walter Zidek2A, Richard Viebahn3D, Nina Babel14DF, Timm H. Westhoff12ACDEF

DOI: 10.12659/AOT.901657

Ann Transplant 2017; 22:431-439

Abstract

BACKGROUND: Hyperuricemia is associated with an increased risk of cardiovascular disease and chronic allograft nephropathy after renal transplantation. It has recently been demonstrated that treatment of asymptomatic hyperuricemia is associated with improved patient and graft survival; although, the underlying mechanisms remain elusive. The present study investigated the association of serum uric acid (SUA) and systemic arterial function after renal transplantation.

MATERIAL AND METHODS: In a cross-sectional study, arterial function was analyzed in 54 renal transplant recipients by means of pulse wave analysis. Different measurement techniques were combined providing data on pulse wave velocity, augmentation index, small and large artery elasticity, and total peripheral vascular resistance.

RESULTS: The prevalence of hyperuricemia was 87.0%, and 33.3% of renal transplant recipients received SUA lowering medication. The median SUA concentration was 7.4 mg/dL. There was no significant difference in all the aforementioned parameters in patients with a SUA <7.4 versus >7.4 mg/dL (p>0.05 each) and no significant differences between hyperuricemic patients with versus without SUA lowering medication. Linear regression analysis between SUA and both pulse wave velocity and augmentation index showed no significant association (p>0.05 each). This finding remained consistent after adjustment of data for age, time on dialysis, time since transplantation, and systolic blood (partial correlation analysis, p>0.05).

CONCLUSIONS: Neither the concentration of SUA nor the pharmacological treatment of hyperuricemia had measurable effects on arterial stiffness. Thus, the beneficial effects of SUA lowering treatment on patient and graft survival cannot be explained by direct effects on arterial function in the study population.

Keywords: hyperuricemia, Kidney Transplantation, Pulse Wave Analysis, Vascular Stiffness

Add Comment 0 Comments

In Press

07 Mar 2024 : Original article  

Long-Term Outcomes with Prolonged-Release Tacrolimus in Kidney Transplantation: A Retrospective Real-World ...

Ann Transplant In Press; DOI: 10.12659/AOT.942167  

07 Mar 2024 : Original article  

Outcomes of Renal Transplantation in ANCA-Associated Vasculitis

Ann Transplant In Press; DOI: 10.12659/AOT.943433  

08 Mar 2024 : Original article  

Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...

Ann Transplant In Press; DOI: 10.12659/AOT.943532  

14 Mar 2024 : Original article  

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study

Ann Transplant In Press; DOI: 10.12659/AOT.943652  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358