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Medical Science Monitor Basic Research

AmJCaseRep
MedSciTechnol

eISSN: 2329-0358

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Successful Use of Hepatitis B Surface Antigen-Positive Liver Grafts – An Effective Source for Donor Organs in Endemic Areas: A Single-Center Experience

Long-Bin Jeng, Ashok Thorat, Horng-Ren Yang, Chun-Chieh Yeh, Te-Hung Chen, Chia-Hao Hsu, Shih-Chao Hsu, Kin-Shing Poon, Ping-Chung Li, Hsueh-Chou Lai, Wen-Pang Su, Cheng-Yuan Peng

(Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan)

Ann Transplant 2015; 20:103-111

DOI: 10.12659/AOT.893032


Background: Due to high prevalence of hepatitis B virus (HBV) infection in Taiwan, liver grafts from donors positive for hepatitis B surface antigen (HBsAg) without progressive disease can be effective alternative source of donor organs. This study aims to prove the safety of living donor liver transplantation (LDLT) using HBsAg-positive liver grafts and its long-term outcome.
Material and Methods: We studied 14 consecutive LDLT recipients that received HBsAg-positive grafts from November 2009 to December 2013 for various indications. All donors were chronic HBsAg carriers with normal liver function tests. Median follow-up was 46 months (range, 35–59).
Results: All the donors and recipients recovered well post-transplant with no reactivation of HBV to date. Two of the recipients died due to extra-hepatic recurrence of HCC. At median follow-up of 46 months, 4-year cumulative survival of recipients was 77.38%.
Conclusions: In endemic areas, HBsAg-positive donor organs can clearly be used effectively under viral immunoprophylaxis. HBV disease reactivation does not appear to be a threat even with hepatitis B immunoglobulin (HBIG)-free antiviral monoprophylaxis regimen. This study thus proves the safety and feasibility of the option of using HBsAg-positive grafts in high-prevalence areas.

Keywords: End stage liver disease, Liver Failure, Acute, Liver Neoplasms

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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