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Medical Science Monitor Basic Research


eISSN: 2329-0358

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Long-term survival after simultaneous pancreas-kidney transplantation with primary function of at least one year – a single-center experience

Tim Schulz, Alexandra Pries, Amke Caliebe, Matthias Kapischke

(Department of General Surgery, Siloah St. Trudpert Klinikum, Pforzheim, Germany)

Ann Transplant 2014; 19:106-111

DOI: 10.12659/AOT.889715

Background: Simultaneous pancreas-kidney transplantation has been established as the treatment of choice for type 1 diabetes patients with renal dysfunction. Patient 1-year survival better than 95% has been achieved using this kind of transplantation. According to the postoperative complication rate (5% mortality), recipients appear to have a survival benefit not earlier than 2 years after transplantation. This study evaluates the long-term benefit of simultaneous pancreas-kidney recipients with functioning grafts after 1 year.
Material and Methods: A retrospective analysis of 176 patients after first transplantation with functioning grafts 1 year after simultaneous pancreas-kidney transplantation was performed.
Results: During the follow-up period starting 1 year after successful transplantation, 7 patients died due to various causes, 13 pancreas grafts (7.4%) and 13 kidney transplants (7.4%) lost their function during the 10-year follow-up period. Chronic graft failure was the most common reason for transplant loss.
Conclusions: Our data support the excellent long-term prognosis of simultaneous pancreas-kidney transplantation recipients with functioning graft 1 year after transplantation.

Keywords: SPK, patient survival, Reasons for death, reasons for organ failure

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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