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Medical Science Monitor Basic Research


eISSN: 2329-0358

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Liver transplantation as an ultimate step in the management of iatrogenic bile duct injury complicated by secondary biliary cirrhosis

Jerzy Lubikowski, Tomasz Chmurowicz, Mariola Post, Konrad Jarosz, Andrzej Białek, Piotr Milkiewicz, Maciej Wójcicki

Ann Transplant 2012; 17(2): 38-44

DOI: 10.12659/AOT.883221

Background:    This report summarizes a single center’s experience with liver transplantation (LT) performed for secondary biliary cirrhosis resulting from iatrogenic bile duct injury (BDI) sustained during cholecystectomy.
    Material/Methods:    Secondary biliary cirrhosis was the indication for LT in 5 (1.7%) out of 300 LTs performed in our center between Feb 2002 and April 2011. We analyzed the medical history of the patients, perioperative course and outcome following LT.
    Results:    The BDI was classified as Strasberg A in 1 case, B in two cases, and E in 2 cases. There was no hepatic arterial or portal vein injury in any patient. All of the surgical repairs prior to the development of cirrhosis were performed in general surgical units. The median time between BDI and listing the patient for LT was 11 years. The cadaveric whole-organ LT was done in all patients using the Piggy-Back technique. All patients are alive with a median follow-up of 53 months.
    Conclusions:    Liver transplantation in patients with secondary biliary cirrhosis appears to result from a series of inadequate multiple surgical repairs following BDI. The immediate referral of such patients to centers with bile duct surgery experience is crucial.

Keywords: Liver Transplantation, Bile duct injury, Liver Cirrhosis, Cholecystectomy

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