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Diagnosis and monitoring of cytomegalovirus infection after liver transplantation in children.

P Kaliciński, A Kamiński, A Prokurat, T Drewniak, M Chrupek, B Ochalska, D Dzierzanowska, M Szymczak, H Ismail, J Pawłowska, W Kamiński

Ann Transplant 1996; 1(2): 13-14

ID: 506515

Cytomegalovirus infection (CMV) complicated the posttransplant course in 9 of 24 children after liver transplantation. We found specific antibodies (IgG and IgM) to be of very low value in diagnosis and monitoring of CMV infection after liver transplantation. Detection of CMV-DNA by PCR method in the blood or urine was very useful for diagnosis, but less for monitoring of the course of disease and its treatment. Measurements of early immediate CMV antigen (IEA), in peripheral blood leucocytes allowed for very early diagnosis of CMV infection and correlated well with the course of disease and response to treatment of the patient.

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