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David Rush, Ray Somorjai, Roxanne Deslauriers, Anthony Shaw, John Jeffery, Peter Nickerson
Ann Transplant 2000; 5(2): 44-49
Chronic renal transplant rejection is a major cause of late transplant failure. About 50% of graft losses after the first year are due to patient death with a functioning transplant. In the survivors, about 50% to 80% of grafts are lost due to chronic rejection . The design of studies to decrease the incidence of chronic rejection is hampered by the very large number of patients and the long-term follow up required . The identification of early surrogate biomarkers for chronic rejection is therefore of considerable interest.
Keywords: subclinical rejection, protocol biopsies, urine spectroskopy