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Medical Science Monitor Basic Research


eISSN: 2329-0358

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Subclinical Rejection- a Potential Surrogate Marker for Chronic Rejection- May Be Diagnosed by Protocol Biopsy or Urine Spectroscopy

David Rush, Ray Somorjai, Roxanne Deslauriers, Anthony Shaw, John Jeffery, Peter Nickerson

Ann Transplant 2000; 5(2): 44-49

ID: 497525

Chronic renal transplant rejection is a major cause of late transplant failure. About 50% of graft losses after the first year are due to patient death with a functioning transplant. In the survivors, about 50% to 80% of grafts are lost due to chronic rejection [1]. The design of studies to decrease the incidence of chronic rejection is hampered by the very large number of patients and the long-term follow up required [2]. The identification of early surrogate biomarkers for chronic rejection is therefore of considerable interest.

Keywords: subclinical rejection, protocol biopsies, urine spectroskopy

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