09 June 2000
Post-TransplanIt Immune Serological Markers May Be Predictive of Chronic Rejection
Ronald H KermanAnn Transplant 2000; 5(2): 24-28 :: ID: 497522
Abstract
Chronic rejection isan important cause ofgraft dysfunction and loss after the first posttransplant year [1].Two working hypotheses have evolved to explainthe etiology of the process. The first is an antigen-dependent phenomenon influenced by early immunological injury whereas the second is related to alloantigen-independent events contributing to progressive chronic graft dysfunction [2,3]. Our study, reported herein, focuses on the antigen-dependent aspects of chronic rejection. Several hypotheses have been proposed to explain the immunologic basis of chronic rejection. The first involvesrecurrent episodes of acute rejection that lead to protracted tissue damage and scarring [2,3].An alternative immune hypothesis to explain chronic rejection is that the immune-regulatory mechanisms that prevent acute rejection playa role in chronic rejection by supporting B cell responses and antibody formation. Therefore, chronic rejection may be a predominantly antibody- mediated form of graft damage..
Keywords: post-transplant antibody, chronic rejection
In Press
08 Mar 2024 : Original article
Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...Ann Transplant In Press; DOI: 10.12659/AOT.943532
14 Mar 2024 : Original article
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort StudyAnn Transplant In Press; DOI: 10.12659/AOT.943652
14 Mar 2024 : Case report
Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...Ann Transplant In Press; DOI: 10.12659/AOT.942358
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860