H-Index
34
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
call: +1.631.629.4327
Mon-Fri 10 am - 2 pm EST

Logo

MSMbanner
Medical Science Monitor Basic Research

AmJCaseRep
MedSciTechnol

eISSN: 2329-0358

Get your full text copy in PDF

Immunologic barriers in pig-to-primate cardiac xenotransplantation

John H Artrip, Pawel Kwiatkowski, Robert E Michler, Silviu Itescu

Ann Transplant 1997; 2(1): 5-11

ID: 497117


Clinical heart transplantation using human cadaver organs remains the most effective therapy for end-stage heart disease; however, the severe shortage of organs has led to alternative strategies utilizing non-human organs (xenografts). In human allotransplantation, the predominant antigenic differences between donor and recipient are confined to the major histocompatibility and blood group antigens. In contrast, a xenograft is able to express a variety of antigens, in addition to the major histocompatibility and blood group antigens, which are not expressed by human cells and can elicit anti-xenograft immunity in human recipients.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree