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Medical Science Monitor Basic Research


eISSN: 2329-0358

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Immunologic barriers in pig-to-primate cardiac xenotransplantation

John H Artrip, Pawel Kwiatkowski, Robert E Michler, Silviu Itescu

Ann Transplant 1997; 2(1): 5-11

ID: 497117

Clinical heart transplantation using human cadaver organs remains the most effective therapy for end-stage heart disease; however, the severe shortage of organs has led to alternative strategies utilizing non-human organs (xenografts). In human allotransplantation, the predominant antigenic differences between donor and recipient are confined to the major histocompatibility and blood group antigens. In contrast, a xenograft is able to express a variety of antigens, in addition to the major histocompatibility and blood group antigens, which are not expressed by human cells and can elicit anti-xenograft immunity in human recipients.

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