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Medical Science Monitor Basic Research

AmJCaseRep
MedSciTechnol

eISSN: 2329-0358

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"One Size Fits All": Immunosuppression in Cardiac Transplantation

David A Baran, Ira D Galin

Ann Transplant 2003; 8(1): 7-9

ID: 496870


Approximately 20 years have passed since the introduction of cyclosporine-based triple therapy for heart transplant recipients. The major thrust of research has been the “middle-drug” between cyclosporine and steroids, and recent efforts have been directed towards newer antibody preparations to induce rapid immunosuppression post-transplant. However, little effort has been paid to attempts to reduce and tailor immunosuppression to specific patients. This paper describes previous work on the individualized dosing of tacrolimus, including patients who are maintained on monotherapy after heart transplantation with tacrolimus alone. The authors conclude that future efforts need to be directed towards individualizing immunosuppression rather than adopting “one-size-fits-all” insitutional protocols.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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