Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

18 June 2002

The renin-angiotensin-aldosterone system (RAAS) and its relation with calcium homeostasis in male obesity

Ozlem Durmus, Mahmut Ilker Yilmaz, Metin Ozata, Erol Bolu, Murat Erdogan, I Caglayan Ozdemir

Med Sci Monit 2002; 8(6): CR430-434 :: ID: 420813

Abstract

BACKGROUND: The aim of our study was to determine whether alterations ofthe vitamin D-endocrine system and the renin-angiotensin-aldosterone system occur in male obesity andinfluence each other.MATERIAL/METHODS: 32 obese male subjects and 21 age-matched healthy male subjectswere enrolled in the study. The parameters measured included serum total calcium (Ca), ionized calcium,magnesium (Mg), phosphorus (P), 25-hydroxyvitamin D (25-OHD), supine and upright aldosterone and reninactivity, and urinary calcium, magnesium, and phosphorus.RESULTS: Serum total Ca and ionized calciumwere slightly, but not significantly lower in obese subjects compared to controls, whereas serum magnesiumphosphorus and PTH levels were significantly higher in the obese subjects. Mean urinary calcium and Mgwere not significantly different, while urinary P was significantly higher in obese subjects. Mean serum25OHD was significantly lower in obese subjects. Supine and upright aldosterone and renin were unrelatedto BMI or fat mass. Supine aldosterone correlated with serum total calcium, ionized calcium and supinerenin activity, but not with other minerals, PTH or 25OHD, whereas upright aldosterone did not correlatewith other parameters. Supine renin activity did not correlate with any parameters, whereas upright renincorrelated with serum Mg and PTH. There were significant correlations between PTH and BMI or fat mass.Urinary Mg was also related to both BMI and fat mass.CONCLUSIONS: Male obesity is associated with increasedserum Mg, P, PTH and urinary P and lower supine aldosterone and 25OHD, but unchanged serum and urinaryCa.

Keywords: Body Mass Index, Case-Control Studies, Magnesium, Obesity, Parathyroid Hormone, Renin-Angiotensin System

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750