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Medical Science Monitor Basic Research


eISSN: 2329-0358

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Increased Plasma TGF-beta 1 Level in Patient with Salivary Gland Carcinoma After Renal Transplantation

M Boratynska, E Watorek, K Falkiewicz, M Banasik

Ann Transplant 2005; 10(2): 16-19

ID: 16808

TGF-beta1 maintains homeostasis of rapidly proliferating cells, therefore is a potential tumor suppressor of non-malignant cells. Malignant transformation alters TGF-beta1 signalling pathway, turning it into a stimulator of tumor progression. We describe the case of 54 year old renal transplant patient with highly increased plasma TGF-beta1 level and planoepithelial carcinoma originating from parotid salivary gland. We discuss the role of TGF-beta1 in promotion of carcinogenesis and probable utility in prognosis of malignancy.

Keywords: renal transplant, Parotid Cancer, TGF-Beta1

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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