06 September 2022>: Original Paper
Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant Recipients
Anna Popova 123ACDE* , Aiga Vasiļvolfa 134ABCDEF , Kārlis Rācenis 12ACD , Renārs Erts 5C , Baiba Šlisere 2BC , Anna Jana Saulīte 12EF , Ieva Ziediņa 14AB , Inese Folkmane 13AB , Harijs Čerņevskis 14DE , Juta Kroiča 2ACDF , Aivars Pētersons 14ACD , Viktorija Kuzema 14ACDEDOI: 10.12659/AOT.936751
Ann Transplant 2022; 27:e936751
Table 2 Correlation between patient serum LRG-1, urine LRG-1, transplant age, and laboratory analysis results after adjustment for patient age.
Parameter | Reference interval | Median value, (Q1, Q3) | Correlation with serum LRG-1 (95% CI) | Correlation with urine LRG-1 (95% CI) | ||
---|---|---|---|---|---|---|
Coefficient, r | P value | Coefficient, r | P value | |||
Transplant age (years) | 6.0 (2; 10) | 0.52 (0.26–0.71) | * | 0.26 (0.53–0.06) | 0.11 | |
Hemoglobin (g/L) | 120–160 | 127 (118; 140) | −0.37 (−0.66–0.01) | 0.01* | −0.15 (−0.49–0.22) | 0.43 |
Serum urea (mmol/L) | 3.2–8.2 | 9.7 (7.55; 12.7) | 0.59 (0.23–0.68) | * | 0.31 (−0.01–0.58) | 0.058 |
Serum creatinine (μmol/L) | 49–90 | 123 (108; 176) | 0.33 (0.01–0.59) | 0.04* | 0.33 (−0.002–0.59) | 0.051 |
eGFR (mL/min/1.73 m) | >90 | 47.1 (33.7; 60) | −0.35 (−0.01 – −0.61) | 0.03* | −0.31 (0.01 – −0.57) | 0.057 |
Serum cystatin C (mg/L) | 0.61–0.95 | 1.78 (1.49; 2.37) | 0.42 (0.08–0.67) | 0.01* | 0.39 (0.02–0.67) | 0.03* |
Serum calcium (mmol/L) | 2.08–2.65 | 2.33 (2.22; 2.41) | −0.27 (−0.57 – −0.07) | 0.12 | −0.34 (−0.64 – −0.04) | 0.08 |
Serum phosphorus (mmol/L) | 0.78–1.65 | 1.10 (1.01; 1.25) | 0.48 (0.14–0.72) | * | 0.10 (−0.27–0.46) | 0.58 |
Serum PTH (ng/ml) | 15–68.3 | 119 (72.5; 180) | 0.29 (−0.08–0.60) | 0.12 | 0.50 (0.19–0.72) | 0.002* |
Serum albumin (g/L) | 35–52 | 44 (43; 46.8) | −0.28 (−0.58 – −0.08) | 0.13 | −0.38 (−0.67 – −0.01) | 0.059 |
Ferritin (ng/mL) | 10–291 | 87.6 (59.5; 135) | 0.21 (−0.16–0.53) | 0.27 | 0.01 (−0.36–0.38) | 0.94 |
Proteinuria (mg/g) | 0–0.5 | 0.235 (0.1; 0.723) | 0.35 (0.02–0.61) | 0.03* | 0.59 (0.01–0.30) | * |
FENa (%) | 1.0 (0.75; 1.6) | 0.35 (0.01–0.62) | 0.04* | 0.11 (−0.21–0.42) | 0.48 | |
Urine NGAL (ng/mL) | 0–132 | 28.9 (8.85; 52.9) | 0.29 (−0.03–0.56) | 0.08 | 0.44 (0.13–0.67) | * |
* p value eGFR – estimated glomerular filtration rate; PTH – parathyroid hormone; FENa – fractional excretion of sodium; NGAL – neutrophil gelatinase-associated lipocalin. |