29 March 2022: Database Analysis
Bioinformatics Identification of Candidate Biomarkers in Endomyocardial Biopsy and Peripheral Blood for Cardiac Allograft Rejection
Kang Luo 1ABCDEFG , Lin Li 2BCDE , Mingyao Meng 2DEFG , Yan Chen 1BC , Zongliu Hou 2EFDOI: 10.12659/AOT.935488
Ann Transplant 2022; 27:e935488
Table 3 Enrichment of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of significance for differentially expressed genes (DEGs) from endomyocardial biopsy samples.
| Category | Term | Description | Count | p-Value |
|---|---|---|---|---|
| GOTERM_MF | GO: 0005515 | Protein binding | 57 | 0.01841913 |
| GOTERM_MF | GO: 0042803 | Protein homodimerization activity | 10 | 0.013700626 |
| GOTERM_MF | GO: 0042802 | Identical protein binding | 12 | 0.00173391 |
| GOTERM_MF | GO: 0005102 | Receptor binding | 11 | 1.49E-05 |
| GOTERM_CC | GO: 0016021 | Integral component of membrane | 39 | 0.00321182 |
| GOTERM_CC | GO: 0005794 | Golgi apparatus | 10 | 0.026519452 |
| GOTERM_CC | GO: 0005886 | Plasma membrane | 34 | 0.001736587 |
| GOTERM_CC | GO: 0070062 | Extracellular exosome | 28 | 3.47E-04 |
| GOTERM_CC | GO: 0005887 | Integral component of plasma membrane | 21 | 1.46E-05 |
| GOTERM_CC | GO: 0016020 | Membrane | 21 | 0.004716471 |
| GOTERM_CC | GO: 0005576 | Extracellular region | 19 | 7.84E-04 |
| GOTERM_CC | GO: 0005615 | Extracellular space | 18 | 2.82E-04 |
| GOTERM_CC | GO: 0006955 | Immune response | 17 | 6.07E-10 |
| GOTERM_CC | GO: 0000139 | Golgi membrane | 11 | 6.63E-04 |
| GOTERM_BP | GO: 0045087 | Innate immune response | 13 | 2.72E-06 |
| GOTERM_BP | GO: 0009986 | Cell surface | 13 | 1.41E-05 |
| GOTERM_BP | GO: 0007165 | Signal transduction | 12 | 0.042676364 |
| GOTERM_BP | GO: 0050852 | T cell receptor signaling pathway | 10 | 8.77E-08 |
| GOTERM_BP | GO: 0006954 | Inflammatory response | 10 | 1.79E-04 |
| KEGG_PATHWAY | hsa04612 | Antigen processing and presentation | 12 | 4.60E-11 |
| KEGG_PATHWAY | hsa05168 | Herpes simplex infection | 12 | 5.45E-07 |
| KEGG_PATHWAY | hsa04514 | Cell adhesion molecules (CAMs) | 10 | 4.23E-06 |
| KEGG_PATHWAY | hsa05164 | Influenza A | 10 | 2.21E-05 |
| The criteria are count ≥10 and value | ||||