Intraoperative Low-Dose Dexmedetomidine Administration Associated with Reduced Hepatic Ischemia-Reperfusion Injury in Pediatric Deceased Liver Transplantation: A Retrospective Cohort Study

15 October 2021: Original Paper

Liang Zhang ^1ABCDEF* , Na Li ^1BEF* , Ling-Li Cui ^1BF , Fu-Shan Xue ^1ADFG* , Zhi-Jun Zhu ^234ADFG*

DOI: 10.12659/AOT.933354

Ann Transplant 2021; 26:e933354

Table 3 Risk factors of moderate-to-severe HIRI in pediatric deceased donor liver transplantation.

	Univariate			Multivariate
	OR	95% CI	P value	OR	95% CI	P value
Age	0.827	0.659–1.037	0.100
Gender (Female)	2.710	0.654–11.237	0.169
Height	0.978	0.952–1.004	0.097
Weight	0.937	0.856–1.026	0.159
Child score	1.380	1.001–1.901	0.049
PELD score	1.028	0.978–1.082	0.280
Graft type (partial)	2.000	0.381–10.511	0.413
Graft weight	0.997	0.993–1.001	0.158
GRWR	1.035	0.974–1.100	0.271
CIT	1.006	1.000–1.013	0.035	1.006	1.000–1.013	0.044
WIT	1.051	0.989–1.117	0.106
Intraoperative DEX use	0.202	0.049–0.836	0.027	0.198	0.045–0.878	0.033
CI – confidence interval; CIT – cold ischemia time; DEX – dexmedetomidine; GRWR – graft-to-recipient weight ratio; HIRI – hepatic ischemia-reperfusion injury; OR – odds ratio; PELD – Pediatric End-stage Liver Disease; WIT – warm ischemia time.