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15 October 2021: Original Paper

Intraoperative Low-Dose Dexmedetomidine Administration Associated with Reduced Hepatic Ischemia-Reperfusion Injury in Pediatric Deceased Liver Transplantation: A Retrospective Cohort Study

Liang Zhang 1ABCDEF* , Na Li 1BEF* , Ling-Li Cui 1BF , Fu-Shan Xue 1ADFG* , Zhi-Jun Zhu 234ADFG*

DOI: 10.12659/AOT.933354

Ann Transplant 2021; 26:e933354

Table 2 Comparison of study outcomes between the control group and the DEX group.

Entire cohort (n=54)Control group (n=26)DEX group (n=28)P value
Peak ALT (IU/L), median (IQR)670 (265–1018)714 (527–1492)407 (230–826)0.048
Peak AST (IU/L), median (IQR)1503 (905–2936)1735 (1255–3068)1378 (559–2947)0.107
Peak LDH (IU/L), median (IQR)1951 (1132–3284)2350 (1652–3078)1677 (757–3506)0.106
Moderate-to-Severe HIRI, n (%)40 (74.1)23 (88.5)17 (60.7)0.020
Severe PRS, n (%)8 (14.8)3 (11.5)5 (17.9)0.706
AD dosage for PRS (μg/kg), median (IQR)0.22 (0.11–0.42)0.24 (0.12–0.44)0.21 (0.10–0.40)0.897
Peak BUN (mmol/L), median (IQR)5.76 (4.38–8.61)5.33 (4.26–6.49)6.13 (4.61–9.93)0.082
Peak Cr (μmol/L), median (IQR)36.0 (32.2–46.2)37.0 (34.0–50.1)35.6 (28.6–42.3)0.177
AKI, n (%)6 (11.1)2 (7.7)4 (14.3)0.670
Ventilation time (hours), median (IQR)2.5 (1.7–3.6)2.1 (1.5–2.8)3.0 (2.0–4.5)0.064
ICU stay (days), mean±SD3.6±1.43.6±1.53.5±1.30.871
Hospital stay (days), median (IQR)21.0 (15.0–30.0)21.5 (17.8–33.0)19.0 (14.0–28.0)0.135
AD – adrenaline; AKI – acute kidney injury; ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Cr – creatinine; DEX – dexmedetomidine; HIRI – hepatic ischemia-reperfusion injury; ICU – Intensive Care Unit; IQR – interquartile range; LDH – lactic dehydrogenase; PRS – post-reperfusion syndrome; SD – standard deviation.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358