15 October 2021>: Original Paper
Intraoperative Low-Dose Dexmedetomidine Administration Associated with Reduced Hepatic Ischemia-Reperfusion Injury in Pediatric Deceased Liver Transplantation: A Retrospective Cohort Study
Liang Zhang 1ABCDEF* , Na Li 1BEF* , Ling-Li Cui 1BF , Fu-Shan Xue 1ADFG* , Zhi-Jun Zhu 234ADFG*DOI: 10.12659/AOT.933354
Ann Transplant 2021; 26:e933354
Table 2 Comparison of study outcomes between the control group and the DEX group.
Entire cohort (n=54) | Control group (n=26) | DEX group (n=28) | P value | |
---|---|---|---|---|
Peak ALT (IU/L), median (IQR) | 670 (265–1018) | 714 (527–1492) | 407 (230–826) | 0.048 |
Peak AST (IU/L), median (IQR) | 1503 (905–2936) | 1735 (1255–3068) | 1378 (559–2947) | 0.107 |
Peak LDH (IU/L), median (IQR) | 1951 (1132–3284) | 2350 (1652–3078) | 1677 (757–3506) | 0.106 |
Moderate-to-Severe HIRI, n (%) | 40 (74.1) | 23 (88.5) | 17 (60.7) | 0.020 |
Severe PRS, n (%) | 8 (14.8) | 3 (11.5) | 5 (17.9) | 0.706 |
AD dosage for PRS (μg/kg), median (IQR) | 0.22 (0.11–0.42) | 0.24 (0.12–0.44) | 0.21 (0.10–0.40) | 0.897 |
Peak BUN (mmol/L), median (IQR) | 5.76 (4.38–8.61) | 5.33 (4.26–6.49) | 6.13 (4.61–9.93) | 0.082 |
Peak Cr (μmol/L), median (IQR) | 36.0 (32.2–46.2) | 37.0 (34.0–50.1) | 35.6 (28.6–42.3) | 0.177 |
AKI, n (%) | 6 (11.1) | 2 (7.7) | 4 (14.3) | 0.670 |
Ventilation time (hours), median (IQR) | 2.5 (1.7–3.6) | 2.1 (1.5–2.8) | 3.0 (2.0–4.5) | 0.064 |
ICU stay (days), mean±SD | 3.6±1.4 | 3.6±1.5 | 3.5±1.3 | 0.871 |
Hospital stay (days), median (IQR) | 21.0 (15.0–30.0) | 21.5 (17.8–33.0) | 19.0 (14.0–28.0) | 0.135 |
AD – adrenaline; AKI – acute kidney injury; ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Cr – creatinine; DEX – dexmedetomidine; HIRI – hepatic ischemia-reperfusion injury; ICU – Intensive Care Unit; IQR – interquartile range; LDH – lactic dehydrogenase; PRS – post-reperfusion syndrome; SD – standard deviation. |