14 September 2021>: Original Paper
Impact of Liver Transplantation on Carbon Monoxide Production as Measured by Arterial Carboxyhemoglobin Levels in Cirrhotic Patients with and without Hepatopulmonary Syndrome
Ralph Llewel Sabang 1ABCDEF* , Mohammad Abu-Hishmeh 2ABC , Roxana Bodin 3DEF , Oleg Epelbaum 4ABCDEFDOI: 10.12659/AOT.932009
Ann Transplant 2021; 26:e932009
Table 1 Baseline demographic and clinical characteristics of the study patients.
All patientsN=39 | With HPSN=14 | Without HPSN=25 | p-Value | |
---|---|---|---|---|
Age | 59±8 | 61±5 | 58±9 | 0.23 |
Male gender | 28 (72%) | 8 (57%) | 20 (80%) | 0.45 |
ESRD | 7 (18%) | 1 (7%) | 6 (24%) | 0.39 |
Ascites | 27 (69%) | 10 (71%) | 17 (68%) | 0.71 |
Hepatic encephalopathy | 15 (38%) | 8 (57%) | 7 (28%) | 0.16 |
MELD score (listing) | 32±5 | 33±4 | 32±5 | 0.35 |
MELD score (physiologic) | 19±10 | 20±10 | 19±10 | 0.87 |
Serum sodium | 136±5 | 135±6 | 136±5 | 0.51 |
Serum creatinine* | 1.08±0.69 | 1.26±0.55 | 1.00±0.78 | 0.97 |
Serum bilirubin | 6±9 | 7±7 | 6±9 | 0.77 |
Serum albumin | 3.1±0.5 | 3.0±0.5 | 3.2±0.5 | 0.22 |
INR | 1.6±0.6 | 1.7±0.8 | 1.5±0.5 | 0.58 |
Indications for liver transplantation** | ||||
HCC | 19 (49%) | 4 (29%) | 15 (60%) | 0.09 |
HCV | 17 (44%) | 6 (43%) | 11 (44%) | 1 |
Alcohol | 11 (28%) | 4 (29%) | 7 (28%) | 1 |
NASH | 8 (11%) | 5 (36%) | 3 (12%) | 0.11 |
Others*** | 3 (8%) | 0 | 3 (12%) | – |
Pre-transplant PaO (mmHg) | 84±16 | 78±17 | 87±14 | 0.069 |
HPS severity**** | ||||
Mild | 7 (50%) | |||
Moderate | 5 (36%) | |||
Severe | 1 (7%) | |||
Very Severe | 1 (7%) | |||
Days from transplant to post-transplant ABG median (IQR) | 151 (91–318) | 136 (69–339) | 187 (93–317) | 0.79 |
ABG – arterial blood gas; ESRD – end-stage renal disease; HCC – hepatocellular carcinoma; HCV – hepatitis C virus; HPS – hepatopulmonary syndrome; INR – international normalized ratio; MELD – Model for End-Stage Liver Disease score; NASH – non-alcoholic steatohepatitis. * Reflects serum creatinine of patients not receiving dialysis; ** some patients had multiple indications for liver transplantation; *** others: Alpha 1 antitrypsin deficiency=1, Primary Sclerosing Cholangitis=1, Cryptogenic Cirrhosis=1; **** HPS severity: [] Mild – ≥80 mmHg, Moderate – |