30 July 2021: Original Paper
Clinical Outcomes of Ablation Compared with Resection for Single Hepatocellular Carcinoma Lesions, as a Primary Treatment or Bridging to Liver Transplantation: A Retrospective Comparative Study
Elizabeth M. Ward 1ABCDEF* , Ahmed Elshawadfy Sherif 12BCDEF* , Stephen O’Neill 3CD , Michael Hughes 1B , Hamish Ireland 4DE , Stephen J. Wigmore 1ADE , Anya Adair 1ADE*DOI: 10.12659/AOT.931980
Ann Transplant 2021; 26:e931980
Table 4 Pattern of recurrence and tumor characteristics with ablative therapies and surgical resection.
| Variable | No recurrence | Local/margin recurrence | De-novo recurrence | Extrahepatic recurrence | P value |
|---|---|---|---|---|---|
| HCC lesion size (mm)* | 20 (15–26.5) | 14.5 (14–19) | 20 (16–21.5) | 24 | 0.29 |
| Serum AFP (ng/mL)* | 6 (4–22) | 4.5 (3–8) | 8 (3.5–15.5) | 14 | 0.56 |
| HCC lesion size (mm)* | 31.5 (21–52) | 53 (33.5–84) | 38.5 (17–78) | 35 (21–47) | 0.64 |
| Serum AFP (ng/mL)* | 8 (3.5–17.5) | 6 (4.5–7) | 15 (3.5–35) | 4 (3–64) | 0.80 |
| Resection margin | 0.71 | ||||
| R0 | 33 (55.0%) | 7 (11.7%) | 9 (15.0%) | 11 (18.3%) | 0.74 |
| R1 | 6 (66.7%) | 0 (0.0%) | 1 (11.1%) | 2 (22.2%) | 0.84 |
| Tumour differentiation | |||||
| Well | 4 (66.7%) | 1 (16.7%) | 0 (0.0%) | 1 (16.7%) | |
| Moderate | 23 (52.3%) | 5 (11.4%) | 6 (13.6%) | 10 (22.7%) | |
| Poor | 11 (61.1%) | 1 (5.6%) | 4 (22.2%) | 2 (11.1%) | |
| Microvascular invasion | |||||
| No | 26 (60.5%) | 4 (9.3%) | 5 (11.6%) | 8 (18.6%) | |
| Yes | 14 (51.9%) | 3 (11.1%) | 5 (18.5%) | 5 (18.5%) | |
| * Nonparametric variables presented with median (interquartile range). | |||||