11 June 2021>: Original Paper
Sequential Organ Failure Assessment (SOFA) Score-Based Factors Predict Early Mortality in High-Risk Patients with Living Donor Liver Transplant
Hao-Chien Hung 1ABC* , Chih-Hsin Shen 2ABC* , Chen-Fang Lee 13ABCDEF , Ssu-Min Cheng 4C , Wei-Chen Lee 13A*DOI: 10.12659/AOT.931045
Ann Transplant 2021; 26:e931045
Table 2 Baseline demographics and clinical characteristics of high SOFA score patients by 3-month mortality.
Factors | Survivors, n=72 | Non-survivors, n=30 | P value |
---|---|---|---|
General information | |||
Recipient age, year-old (>60) | 18 (25.0%) | 11 (36.7%) | 0.234 |
Recipient sex (Male) | 52 (72.2%) | 21 (70.0%) | 0.821 |
Recipient BMI, kg/m | 24.6±3.6 | 24.6±4.0 | 0.992 |
Donor age, year-old (>45) | 5 (6.9%) | 7 (23.3%) | |
Donor gender (Male) | 33 (45.8%) | 14 (46.7%) | 0.939 |
Donor BMI, kg/m | 22.8±2.9 | 24.0±3.0 | 0.073 |
MELD score | 25.6±10.2 | 23.1±11.2 | 0.279 |
HBV infection | 49 (68.1%) | 16 (53.3%) | 0.159 |
HCV infection | 22 (30.6%) | 8 (26.7%) | 0.694 |
Alcohol use | 29 (40.3%) | 10 (33.3%) | 0.511 |
HCC | 18 (25.0%) | 4 (13.3%) | 0.192 |
Pre-transplant RFA history | 3 (4.3%) | 0 (0.0%) | 0.258 |
Abdominal operation history | 13 (18.6%) | 4 (13.8%) | 0.566 |
Child-Pugh class (B/C) | 21/46 (29.2/63.9%) | 13/15 (43.3/50%) | 0.375 |
Ascites, mL (>3000) | 34 (47.2%) | 14 (46.7%) | 0.959 |
Graft weight, gm | 616.9±130.0 | 550.7±171.9 | 0.064 |
GRWR,% ( | 16 (22.2%) | 13 (43.3%) | |
Blood loss, mL (>3000) | 26 (36.1%) | 10 (33.3%) | 0.789 |
Cold ischemia time, minutes (>60) | 14 (19.4%) | 9 (30.0%) | 0.245 |
Warm ischemia time, minutes (>60) | 1 (1.4%) | 3 (10.0%) | |
OP time, minutes (>700) | 16 (22.2%) | 11 (36.7%) | 0.132 |
SOFA on POD 7 | |||
Total SOFA score | 9.3±1.5 | 10.8±2.2 | |
Cardiovascular component (>0) | 4 (5.6%) | 7 (23.3%) | |
Coagulation component (>2) | 57 (79.2%) | 25 (83.3%) | 0.629 |
Respiratory component (>2) | 10 (13.9%) | 4 (13.3%) | 0.941 |
Renal component (>1) | 44 (61.1%) | 23 (76.7%) | 0.132 |
Liver component (>2) | 45 (62.5%) | 27 (90.0%) | |
CNS component (>0) | 23 (31.9%) | 14 (46.7%) | 0.159 |
Events | |||
Infection | 21 (29.2%) | 15 (50.0%) | 0.045 |
Rejection | 5 (6.9%) | 7 (23.3%) | |
Vascular complication | 0 (0.0%) | 4 (13.3%) | |
Cardiopulmonary-related | 2 (2.8%) | 2 (6.7%) | 0.357 |
Bleeding | 2 (2.8%) | 2 (6.7%) | 0.357 |
ICU stay length, days | 28.4±23.4 | 27.5±13.9 | 0.256 |
Ventilator dependence* | 19 (26.4%) | 16 (53.3%) | 0.009 |
SOFA – Sequential Organ Failure Assessment Score; BMI – body mass index; MELD – model for end-stage liver disease; OP – operation; BMI – body mass index; HBV – hepatitis B virus; HCV – hepatitis C virus; HCC – hepatocellular carcinoma; RFA – radiofrequency ablation; GRWR – graft-recipient weight ratio; CNS – central nervous system. The value within parentheses indicates optimal cut-off value to predict 3-month mortality after liver transplantation. * Ventilator dependence was defined as failed weaning within 48 hours after transplant or re-intubation of endotracheal tube within 7 days after extubating. |