09 February 2021: Original Paper
Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation
Kumiko Muta 1ABCDEF* , Mineaki Kitamura 1ABCDE , Masaaki Hidaka 2BE , Yuki Ota 1AB , Takanobu Hara 2BE , Akihiko Soyama 2BD , Satoshi Miuma 3BE , Hisamitsu Miyaaki 3BE , Kazuhiko Nakao 3BE , Susumu Eguchi 2BDE , Hiroshi Mukae 4DE , Tomoya Nishino 1ADEDOI: 10.12659/AOT.928858
Ann Transplant 2021; 26:e928858
Table 3 Univariate logistic regression analysis for elevated eGFR 1 year after living donor liver transplantation.
| Odds ratio | 95% CI | p Value | |
|---|---|---|---|
| Age (yeas old) | 1.00 (per 1 year old) | 0.97–1.0 | 0.95 |
| Male | 0.58 (vs Female) | 0.32–1.06 | 0.78 |
| HCV antibody positive | 1.21 (vs negative) | 0.65–2.24 | 0.55 |
| Pretransplant diabetes mellitus | 1.20 (vs no diabetes mellitus) | 0.59–2.43 | 0.62 |
| Pretransplant hypertension | 1.02 (vs no hypertension) | 0.45–2.35 | 0.96 |
| Pretransplant diuretics | 2.45 (vs no diuretics) | 1.26–4.76 | 0.008 |
| Pretransplant hemoglobin | 0.81 (per 1 mg/dL) | 0.70–0.94 | 0.005 |
| Pretransplant albumin | 0.69 (per 1 g/dL) | 0.41–1.17 | 0.17 |
| Pretransplant eGFR | 0.94 (per 1ml/min/1.73 m) | 0.92–0.95 | |
| Pretransplant urine test abnormalities | 0.91 (vs no abnormalities) | 0.30–2.75 | 0.87 |
| Trough value of TAC 1 year after LDLT | 0.82 (per 1 ng/mL) | 0.71–0.95 | 0.01 |
| Trough value of TAC 1 year after LDLT | 2.11 (vs ≥5 ng/mL) | 1.04–4.28 | 0.04 |
| Posttransplant use of TAC +Mycophenolate mofetil | 1.97 (vs no use) | 0.98–3.99 | 0.06 |
| 95% CI – 95% confidence interval; eGFR – estimated glomerular filtration rate; HCV – hepatitis C virus; LDLT – living donor liver transplantation; TAC – tacrolimus. | |||