03 November 2020: Original Paper
Comorbidity Burden May Be Associated with Increased Mortality in Patients with Severe Acute Liver Injury Referred for Liver Transplantation
Lindsey Steiner-Temnykh 1ABCDEF , Lara Dakhoul 2ABCDEF , James Slaven 3ACDE , Lauren Nephew 2BCDEF , Kavish R. Patidar 2BCDEF , Eric Orman 2BCDEF , Archita P. Desai 2BCDEF , Eduardo Vilar-Gomez 2BCDEF , Chandrashekhar Kubal 4BCDEF , Burcin Ekser 4BCDEF , Naga Chalasani 2ABCDEF , Marwan Ghabril 2ABCDEF*DOI: 10.12659/AOT.926453
Ann Transplant 2020; 25:e926453
Supplementary Table 1 The conditions composing the Charlson Comorbidity Index as described by Charlson et al. [9].
| Charlson Comorbidity Index comorbid conditions (score weight) | Clinical scenarios |
|---|---|
| Acquired Immune Deficiency Syndrome (6) | Not just HIV positive, includes patients with HIV, CD4 count |
| Metastatic solid tumor (6) | Clinical review |
| Non-metastatic solid tumor (2) | Exclude if >5years from dx,Exclude non-melanoma malignant neoplasm of skin |
| Lymphoma (2) | Includes lymphosarcoma, Hodgkins Waldenstrom’s, macroglobulinemia, myeloma, and other lymphomas |
| Leukemia (2) | Includes acute or chronic myelogenous or lymphocytic leukemia, and polycythemia vera |
| Moderate or severe renal disease (2) | |
| Hemiplegia or paraplegia (2) | Clinical diagnosis |
| Diabetes with end organ damage (2) | With end-organ damage includes Retinopathy, neuropathy, nephropathy or brittle diabetes |
| Diabetes without complications (1) | Without end-organ damage includes all others treated with insulin or oral hypoglycemics, but not diet alone |
| Liver disease, moderate to severe (3) | Moderate: cirrhosis with portal hypertension without variceal bleedSevere: Cirrhosis with variceal bleed |
| Liver disease, mild (1) | Mild: chronic hepatitis, no portal hypertension |
| Peptic ulcer disease (1) | Includes patients who have required treatment for peptic ulcer disease, including those who have bled from ulcers |
| Connective tissue disease (1) | Systemic lupus erythematous, polymyositis, mixed connective tissue disease, polymyalgia rheumatic, rheumatoid arthritis, etc |
| Chronic obstructive pulmonary disease (1) | Clinical review and not based on spirometry testing |
| Dementia (1) | Includes patients with chronic cognitive deficits |
| Cerebrovascular disease or transient ischemic attack (TIA) (1) | Includes patients with a history of stroke with minor or no residua and TIA |
| Peripheral Vascular disease (1) | Includes patients with intermittent claudication or those who had a bypass for arterial insufficiency, those with gangrene or acute arterial insufficiency, and those with untreated thoracic or abdominal aortic aneurysm (6 cm or more) |
| Congestive heart failure (1) | Clinical review and includes patients who have had exertional or paroxysmal nocturnal dyspnea and who have responded symptomatically (or on physical exam) to digitalis, diuretics, or afterload reducing agents |
| Myocardial infarction (1) | Includes patients with one or more definite or probable Myocardial infarctions. These patients had been hospitalized and had ECG and/or enzyme changes. Not just ECG changes only |