03 November 2020: Original Paper
Comorbidity Burden May Be Associated with Increased Mortality in Patients with Severe Acute Liver Injury Referred for Liver Transplantation
Lindsey Steiner-Temnykh 1ABCDEF , Lara Dakhoul 2ABCDEF , James Slaven 3ACDE , Lauren Nephew 2BCDEF , Kavish R. Patidar 2BCDEF , Eric Orman 2BCDEF , Archita P. Desai 2BCDEF , Eduardo Vilar-Gomez 2BCDEF , Chandrashekhar Kubal 4BCDEF , Burcin Ekser 4BCDEF , Naga Chalasani 2ABCDEF , Marwan Ghabril 2ABCDEF*DOI: 10.12659/AOT.926453
Ann Transplant 2020; 25:e926453
Supplementary Table 4 The association of the Charlson Comorbidity Index with 30-day mortality or liver transplantation by multiple logistic regression, and 90-day mortality by multivariable competing risk regression analyses when modeled in the 114 patients with acute liver failure with different severity of illness scores.
| Model covariates | *MELD model | *CLIF-SOFA model | ALFSG model | Kings College Criteria model | ||||
|---|---|---|---|---|---|---|---|---|
| ,# | ,# | |||||||
| Charlson Comorbidity Index | 1.14 (0.9–1.5) | 0.3 | 1.03 (0.8–1.3) | 0.8 | 1.19 (0.9–1.5) | 0.16 | 1.08 (0.9–1.3) | 0.5 |
| Underlying liver disease | 0.5 (0.1–2.1) | 0.3 | 0.9 (0.3–3.2) | 0.9 | 0.9 (0.3–3.5) | 0.9 | 1.4 (0.5–4.2) | 0.6 |
| Charlson Comorbidity Index | 1.14 (0.98–1.33) | 0.08 | 1.11 (0.96–1.3) | 0.16 | 1.14 (0.98–1.32) | 0.07 | 1.11 (0.97–1.3) | 0.13 |
| Underlying liver disease | 0.4 (0.1–1.2) | 0.11 | 0.7 (0.3–1.6) | 0.4 | 0.7 (0.3–1.8) | 0.4 | 0.7 (0.3–1.6) | 0.4 |
| ALFSG – Acute Liver Failure Study Group; CLIF-SOFA – chronic liver failure-sequential organ failure assessment; KCC – Kings College Criteria; MELD – model for endstage liver disease. * Analyses were controlled for gender and APAP etiology of liver injury based on their impact in the non-adjusted analysis (p-value ≤0.1). The results were similar when the multiple logistic regression was controlled for interactions of gender and APAP etiology of liver disease. # Analysis was controlled for patient age based on its impact in the unadjusted analysis (p-value ≤0.1). | ||||||||