Predictors of Mortality During Initial Liver Transplant Hospitalization and Investigation of Causes of Death

04 December 2020: Original Paper

Ni Gong ^1BE , Chao Jia ^2CDF , He Huang ^3CEF , Jing Liu ^4BCD , XueTing Huang ^4CF , QiQuan Wan ^4ADG*

DOI: 10.12659/AOT.926020

Ann Transplant 2020; 25:e926020

Table 2 Univariate analysis of risk factors associated with mortality during initial LT hospitalization.

Characteristics	Survival group	Death group	P
Total, n (%)	96 (93.2)	7 (6.8)
Univariate analysis
Donor age (yrs)	40.1±14.2	45.9±8.9	0.288
Donor Male gender, n (%)	82 (85.4)	7 (100.0)	0.277
Cold ischemia time, mean hrs±SD	5.4±1.4	5.8±1.3	0.721
Recipient age, mean yrs±SD	47.6±9.8	50.0±13.1	0.529
Recipient male gender, n (%)	81 (84.4)	5 (71.4)	0.373
Acute hepatic necrosis, n (%)	17 (17.7)	5 (71.4)	^*
Pretransplant diabetes, n (%)	8 (8.3)	0 (0)	0.426
Median MELD score at LT (IQR)	31.4 (21.4–38.2)	40.0 (20.4–40.0)	0.370
Pretransplant infections, n (%)	45 (46.9)	4 (57.1)	0.599
Hospital stay prior to LT, mean days±SD	7.2±10.8	6.6±8.3	0.872
Median duration of hrs of operation (IQR)	6.3 (5.7–7.0)	6.6 (5.6–6.8)	0.768
Red blood cell infusions, mean units±SD	16.1±7.2	18.7±7.7	0.350
Induction therapy, n (%)	10 (10.4)	1 (14.3)	0.749
The use of Tacrolimus, n (%)	93 (96.9)	4 (57.1)	^*
Reoperation, n(%)	4 (4.2)	0 (0)	0.582
Postoperative bacteremia, n (%)	1 (1.0)	4 (57.1)	^**
Postoperative pneumonia, n (%)	35 (36.5)	6 (85.7)	^*
Acute rejection, n(%)	8 (8.3)	0 (0)	0.426
Creatinine on day 3 post-LT >2 mg/dL, n (%)	7 (7.3)	4 (57.1)
ALT on day 1 post-LT >1800 μmol/L	10 (10.4)	5 (71.4)	^*
ICU stay ≥7 days, n (%)	24 (25.0)	6 (85.7)	^*
Whole hospital stay, mean days±SD	34.5±13.3	26.4±20.3	0.138
CI – confidence interval; ICU – Intensive Care Unit; IQR – interquartile range; LT – liver transplantation; MELD – model for end stage liver disease; SD – standard deviation. ^* χ test; ^** Fisher’s exact test.