18 August 2020: Original Paper
What Awaits on the Other Side: Post-Lung Transplant Morbidity and Mortality After Pre-Transplant Hospitalization
Darya Rudym 1ACDEF , Luke Benvenuto 1ABCDE , Joseph Costa 2B , Meghan Aversa 1AB , Hilary Robbins 1AB , Lori Shah 1AB , Hanyoung Kim 1B , Bryan P. Stanifer 2AB , Joshua Sonett 2AB , Frank D’Ovidio 2AB , Selim M. Arcasoy 1ABCDEF*DOI: 10.12659/AOT.922641
Ann Transplant 2020; 25:e922641
Table 1 Baseline characteristics.
| Hospitalized (n=114) | Outpatient (n=334) | p Value | |
|---|---|---|---|
| Age at transplant, mean (SD), years | 47.8 (15.7) | 55.8 (12.5) | |
| Male, No. (%) | 60 (52.6) | 182 (54.5) | 0.731 |
| Race/Ethnicity, No. (%) | 0.018 | ||
| White | 79 (69.3) | 258 (77.3) | |
| African American | 12 (10.5) | 42 (12.6) | |
| Hispanic | 10 (8.8) | 23 (6.9) | |
| Asian | 10 (8.8) | 9 (2.7) | |
| Other | 3 (2.6) | 2 (0.6) | |
| Diagnosis group, No. (%) | |||
| A (obstructive lung disease) | 8 (7.0) | 59 (17.7) | |
| B (pulmonary vascular disease) | 8 (7.0) | 33 (9.9) | |
| C (cystic fibrosis) | 31 (27.2) | 39 (11.7) | |
| D (restrictive lung disease) | 67 (58.8) | 203 (60.8) | |
| Body mass index, mean (SD), kg/m | 23.8 (4.9) | 25.0 (4.4) | 0.016 |
| LAS, mean (SD) | 84.5 (14.0) | 46.5 (11.2) | |
| 6MWT, mean (SD), feet | 400 (366) | 872 (394) | |
| Days on waiting list, mean (SD) | 115.3 (165.3) | 185.0 (245.0) | 0.005 |
| Hospital Location, No (%) | |||
| Intensive Care Unit | 84 (73.7) | – | |
| Step down unit | 14 (12.3) | – | |
| Medicine floors | 16 (14.0) | – | |
| At transplant | |||
| FEV1, mean (SD),% predicted | 39.1 (18.9) | 36.4 (18.9) | 0.189 |
| FVC, mean (SD),% predicted | 44.9 (17.8) | 44.0 (16.7) | 0.638 |
| Serum creatinine, mean (SD), mg/liter | 0.68 (0.24) | 0.81 (0.23) | |
| Mean PA pressure, mean (SD), mmHg | 31.5 (15.5) | 25.8 (9.8) | |
| Chronic hypercapneic RF, No. (%) | 38 (33.3) | 9 (2.7)* | |
| Invasive mechanical ventilation | 38 | 2 | |
| Non-invasive ventilation | – | 7 | |
| ECMO Support, No (%) | 51 (44.7) | – | |
| * Two patients receiving nightly MV via tracheostomy at home, seven patients receiving CPAP. Data presented as a percent or mean. SD – standard deviation; LAS – lung allocation score; 6MWT – six-minute walk test; FEV1 – forced expiratory volume in the first second; FVC – forced vital capacity; PA – pulmonary artery; RF – respiratory failure; ECMO – extracorporeal membrane oxygenation; CPAP – continuous positive airway pressure. | |||