14 July 2020>: Original Paper
Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats
Shinichi Nakanuma 1ABCDEFG* , Hidehiro Tajima 1AC , Hiroyuki Takamura 1ACG , Seisho Sakai 1A , Ryosuke Gabata 1B , Mitsuyoshi Okazaki 1B , Hiroyuki Shinbashi 1B , Yoshinao Ohbatake 1B , Isamu Makino 1B , Hironori Hayashi 2A , Tomoharu Miyashita 1AC , Sachio Fushida 1A , Tetsuo Ohta 1ACEDOI: 10.12659/AOT.922306
Ann Transplant 2020; 25:e922306
Table 1 Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (T-Bil), direct bilirubin (D-Bil), lactate dehydrogenase (LDH), hyaluronic acid (HA) levels, and platelet counts 5 h after reperfusion: Serum AST, ALT, T-Bil, D-Bil, LDH, and HA were significantly elevated in the ischemia-reperfusion (IR) group compared with those of the sham group. Serum AST and D-Bil levels were significantly lower in the IR+milrinone group than in the IR group. Platelet counts were significantly decreased in the IR group as compared with those of the sham group. Platelet counts were significantly higher in the IR+milrinone group than in the IR group.
Variable | Sham | IR | IR+milrinone |
---|---|---|---|
AST (IU/L) | 144±21 | 1271±640** | 749±291# |
ALT (IU/L) | 33±6 | 764±504** | 471±211 |
T-Bil (mg/dL) | 0.033±0.007 | 0.114±0.045** | 0.086±0.019 |
D-Bil (mg/dL) | 0.016±0.006 | 0.077±0.015** | 0.061±0.007## |
LDH (IU/L) | 492±191 | 2289±2535* | 876±679 |
Hyaluronic acid (ng/dL) | 33.9±7.9 | 51.9±14.4** | 49.9±14.9 |
Platelets (10/μL) | 101.1±9.7 | 88.1±17.7* | 103.4±12.3# |
* Significantly ( ** Significantly ( # Significantly ( ## Significantly ( |