17 July 2020: Original Paper
Kidney Transplantation and “Sex Mismatch”: A 10-Year Single-Center Analysis
Karol Graňák 1ABCDE , Lea Kováčiková 1ABC , Petra Skalová 1AB , Matej Vnučák 1BDE , Juraj Miklušica 1ABCD , Ľudovít Laca 1ABC , Marián Mokáň 2FG , Ivana Dedinská 1ACEF*DOI: 10.12659/AOT.921117
Ann Transplant 2020; 25:e921117
Table 7 Cox proportional hazards model (acute rejection in 1st year after KT).
| Acute rejection (first year) | Hazard ratio | 95% CI | P-value |
|---|---|---|---|
| Age of donor at the time of procurement | 1.2083 | 0.6198–2.3554 | 0.5785 |
| Age of donor at the time of procurement 45–59 years old | 1.0982 | 0.6453–1.8688 | 0.7300 |
| Age of donor at the time of procurement ≥60 years old | 1.2855 | 0.6002–2.7532 | 0.5180 |
| BMI of donor | 0.3197 | 0.0430–2.3789 | 0.2654 |
| BMI of donor 20–24.9 kg/m | 0.9805 | 0.4397–2.1865 | 0.9616 |
| BMI of donor 25–29.9 kg/m | 0.9100 | 0.3965–2.0886 | 0.8240 |
| BMI of donor ≥30 kg/m | 1.4936 | 0.6417–3.4763 | 0.3520 |
| ECD donor | 1.3591 | 0.6982–2.6456 | 0.3667 |
| eGFR of the donor at the time of procurement ≥60 ml/min | 1.0202 | 0.5272–1.9744 | 0.9526 |
| eGFR of the donor at the time of procurement 30–59 ml/min | 1.0623 | 0.5564–2.0282 | 0.8546 |
| QVPU of the donor before procurement ≥0.300 G/24 hours | 1.6399 | 0.9461–2.8427 | 0.0780 |
| Age of recipient | 1.0525 | 0.6146–1.8023 | 0.8522 |
| Age of recipient ≥45 years old | 0.9864 | 0.5685–1.7117 | 0.9612 |
| CIT | 0.8790 | 0.3984–1.9393 | 0.7494 |
| CIT 360–719 min | 1.0299 | 0.6042–1.7553 | 0.9139 |
| CIT ≥720 min | 1.1120 | 0.6203–1.9937 | 0.7214 |
| DGF* | 1.9845 | 1.0015–3.9323 | |
| Induction: basiliximab/daclizumab | 0.8589 | 0.4569–1.6146 | 0.6367 |
| Induction: thymoglobulin | 0.2108 | 0.0746–0.5961 | 0.0033 |
| Tacrolimus | 0.7283 | 0.3912–1.3559 | 0.3174 |
| Acute rejection in anamnesis** | 0.2913 | 0.0394–2.1564 | 0.2272 |
| Female donor/female recipient | 0.9416 | 0.4607–1.9243 | 0.8689 |
| Female donor/male recipient | 1.8992 | 1.0338–3.4891 | |
| Male donor/female recipient | 0.6889 | 0.3865–1.2281 | 0.2065 |
| BMI – body mass index; ECD – expanded criteria donors; eGFR – estimated glomerular filtration rate (pursuant to CKD/EPI formula); QVPU – quantitative proteinuria; CIT – cold ischemia time; DGF – delayed graft function; D – day; M – month; Y – year. * Need for dialysis treatment in the first week after kidney transplantation; ** follow up: 1 year. | |||