Scimago Lab
powered by Scopus
call: +1.631.629.4327
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


eISSN: 2329-0358

Infertility in Female and Male Solid Organ Recipients – From Diagnosis to Treatment: An Up-To-Date Review of the Literature

Iwona Szymusik, Damian Warzecha, Mirosław Wielgoś, Bronisława Pietrzak

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland

Ann Transplant 2020; 25:e923592

DOI: 10.12659/AOT.923592

Available online: 2020-09-11

Published: 2020-11-20

ABSTRACT: Around 20% to 30% of patients after solid organ transplantation are of reproductive age. The estimated rate of infertility in this group is slightly higher than in the general population. Choosing the optimal moment for pregnancy in transplanted patients plays a pivotal role, regardless of the method of conception. The first part of this article presents an up-to-date review of the problem of infertility in female and male solid organ recipients, with special attention to the influence of specific immunosuppressive drugs on semen parameters. The second part discusses the current knowledge regarding infertility treatment and the results of assisted reproductive techniques in this specific group of patients.
Despite restoring gonadal functions after transplantation, the patients should be informed about possible negative effects of medications on fertility, course of pregnancy, and the fetus. Interdisciplinary care should always be provided for infertile graft recipients, especially women, as it ensures safety both for the graft and for the potential gestation. The process of infertility diagnosis and tools used for that purpose are the same in transplanted patients as in the general population. The treatment with assisted reproductive techniques is acceptable and gives favorable results as long as patients are managed rationally, with special attention paid to prevention of iatrogenic complications.

Keywords: Hormones, Immunosuppression, Infertility, Kidney Transplantation, Semen