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eISSN: 2329-0358

Urinary and Serum Biomarkers for Prediction of Acute Kidney Injury in Patients Undergoing Liver Transplantation

Lidia Lewandowska, Jolanta Małyszko, Joanna Matuszkiewicz-Rowińska

Department of Nephrology, Dialysotherapy, and Internal Medicine, Medical University of Warsaw, Warsaw, Poland

Ann Transplant 2019; 24:291-297

DOI: 10.12659/AOT.914975

Available online:

Published: 2019-05-21

ABSTRACT: Acute kidney injury (AKI) is a frequent and serious complication of orthotopic liver transplantation (OLT), with a significant impact on mortality, graft survival, and chronic kidney disease. Currently, the diagnosis of AKI is based on changes in serum creatinine, which is a late marker, usually rising when there is already significant damage to the renal parenchyma. During the last 2 decades, various biomarkers have been studied in many clinical situations, mostly after cardiac surgery, in drug-induced AKI, or in sepsis. The present article summarizes the data on those biomarkers that have been evaluated for the prediction of AKI in patients undergoing OLT.

Keywords: acute kidney injury, Biological Markers, Liver Transplantation