08 August 2017 : Original article
Comparative Peripheral Blood T Cells Analysis Between Adult Deceased Donor Liver Transplantation (DDLT) and Living Donor Liver Transplantation (LDLT)Jong Man Kim1ABCDEF, Choon Hyuck David Kwon1BCDF, Jae-Won Joh1ADEFG*, Gyu-Seong Choi1BCD, Eun-Suk Kang2ABCDE, Suk-Koo Lee1DEF
Ann Transplant 2017; 22:475-483
BACKGROUND: T lymphocytes are an essential component of allograft rejection and tolerance. The aim of the present study was to analyze and compare the characteristics of T cell subsets in patients who underwent deceased donor liver transplantation (DDLT) versus living donor liver transplantation (LDLT).
MATERIAL AND METHODS: Between April 2013 and June 2014, 64 patients underwent adult liver transplantation. The distribution of peripheral blood T lymphocyte subsets before transplantation and at 4, 8, 12, and 24 weeks post-transplantation were monitored serially.
RESULTS: In the serial peripheral blood samples, the absolute CD3+ T cell counts in the LDLT group were higher than those in the DDLT group (p=0.037). The CD4+, CD8+, CD4/CD8, Vδ1, Vδ2, and γδ T cell counts did not change significantly over time in either group. The Vδ1/Vδ2 ratio was higher in patients with cytomegalovirus (CMV) infection than in patients without CMV infection (0.12 versus 0.26; p=0.033). The median absolute CD3+ and CD8+ T cell counts in patients with biopsy-proven acute rejection (BPAR) were 884 (range, 305–1,320) and 316 (range, 271–1,077), respectively, whereas they were 320 (range, 8–1,167) and 257 (range, 58–1,472) in patients without BPAR. The absolute CD3+ and CD8 T cell counts were higher in patients with BPAR than in patients without BPAR (p=0.007 and p=0.039, respectively).
CONCLUSIONS: With the exception of CD3+ T cells, T cell populations did not differ significantly between patients who received DDLT versus LDLT. In liver transplantation patients, CMV infection and BPAR were closely associated with T cell population changes.
Keywords: Cytomegalovirus Infections, Graft Rejection, Graft Survival, Liver Transplantation, T-Lymphocyte Subsets
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