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Medical Science Monitor Basic Research


eISSN: 2329-0358

Follow-Up of Pediatric Liver Transplant Patients After Reaching Adulthood

Justyna Rajchert, Monika Rosa, Joanna Pawłowska, Milosz Parczewski, Marta Wawrzynowicz-Syczewska

Department of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, Szczecin, Poland

Ann Transplant 2016; 21:644-648

DOI: 10.12659/AOT.899462

Available online: 2016-10-18

Published: 2016-10-18


BACKGROUND: Despite excellent transplantation results, there is a vulnerable period of time in the post-transplant management of pediatric liver recipients, which is the time when a child becomes an adolescent. This period of psychological distress influences compliance and may result in premature transplant failure and graft loss. We performed a retrospective review of pediatric liver transplant recipients, transferred to our service for adults, in order to identify key issues associated with transition into the adult care.
MATERIAL AND METHODS: We analyzed medical files of 20 liver recipients transferred from pediatric post-transplant outpatient clinic to the post-transplant service for adults, since year 2000 until December 2015. For survival analyses, Kaplan-Meier model with log-rank test and Cox proportional hazards regression model, to calculate hazard ratio (HR), were used.
RESULTS: Survival rate exceeds 90% in the study population. The major complication was late acute rejection, in most instances due to non-compliance. There were single cases of recurrent liver disease and de novo graft disorders.
CONCLUSIONS: Dedicated service for young people may be needed to optimize outcomes.

Keywords: Adolescent, Liver Transplantation, Patient Compliance, Survival Analysis