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09 August 2016 : Original article  

Pharmacokinetics of a Once-Daily Dose of Tacrolimus Early After Liver Transplantation: With Special Reference to CYP3A5 and ABCB1 Single Nucleotide Polymorphisms

Yoichi MiyataABCDEF, Nobuhisa AkamatsuABCDEF, Yasuhiko SugawaraD, Junichi KanekoB, Takehito YamamotoD, Hiroshi SuzukiD, Junichi AritaD, Yoshihiro SakamotoD, Kiyoshi HasegawaD, Sumihito TamuraD, Norihiro KokudoA

DOI: 10.12659/AOT.898358

Ann Transplant 2016; 21:491-499

Abstract

BACKGROUND: The aim of the present study was to investigate the pharmacokinetics of the once-daily tacrolimus formulation (QD form) in relation to polymorphisms of the donor cytochrome P450 family 3 sub-family A polypeptide 5 (CYP3A5) gene and recipient adenosine triphosphate-binding cassette sub-family B member 1 (ABCB1) gene.

MATERIAL AND METHODS: A total of 80 consecutive living-donor liver transplant (LDLT) recipients were started on the QD form of tacrolimus (day 1), and 60 patients were completely followed for 7 days early after liver transplantation in order to evaluate the pharmacokinetics.

RESULTS: The concentration/dose (C/D) ratio in recipients with the donor CYP3A5 *1 allele was significantly lower throughout the observation period compared with those with the CYP3A5 genotype *3/*3 (p<0.001), while no effect of single-nucleotide polymorphisms (SNPs) of ABCB1 was observed. The administered doses required to achieve the target trough level were significantly higher on day 7 than on day 1 among all groups, regardless of the differences in the SNPs, especially among those with donor CYP3A5 *1 allele. The tacrolimus concentration was kept within the targeted level all through the study regardless of SNPs.

CONCLUSIONS: The donor CYP3A5 *1 allele correlated with the lower C/D ratio after administration of the QD form, and higher doses of QD-form tacrolimus and careful monitoring for the trough level should be considered, especially in recipients with the donor CYP3A5 *1 allele.

Keywords: Cytochrome P-450 CYP3A, Liver Transplantation, Pharmacokinetics, Tacrolimus

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358