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08 July 2016 : Original article  

Effectiveness of Fractionated Plasma Separation and Absorption as a Treatment for Amanita Phalloides Poisoning

Rafał StankiewiczABCDEF, Zbigniew LewandowskiCD, Marcin KotulskiBF, Waldemar PatkowskiD, Marek KrawczykAD

DOI: 10.12659/AOT.897351

Ann Transplant 2016; 21:428-432

Abstract

BACKGROUND: Fractionated plasma separation and absorption (FPSA) is an extracorporeal liver support method that detoxifies accumulated toxins. There are limited data of its use in the treatment of Amanita phalloides intoxication. The objective of this study was to investigate whether FPSA before liver transplantation improves patients’ short-term post liver transplantation survival in Amanita phalloides poisoning.

MATERIAL AND METHODS: The study population consisted of ten patients who had liver transplantation (LT) due to acute liver failure (ALF) caused by Amanita phalloides poisoning. Six patients were treated with FPSA before liver transplantation. All the patients who were started on FPSA were also placed on the liver transplantation list according to emergent liver transplantation criteria.

RESULTS: Patients treated with FPSA were in a more severe clinical condition presenting in higher mean MELD, total bilirubin, INR and ammonia along with more frequent hypoglycemia and hepatic encephalopathy grade 3/4. FPSA group had longer mean waiting time on the recipient list (3.5 vs. 1.25 days) but inferior thirty-day survival rate (16.5% vs. 100%).

CONCLUSIONS: When conservative medical modalities are ineffective, the only treatment for Amanita phalloides poisoning is a liver transplant. Although FPSA treated patients had inferior post-LT survival, FPSA was found to prolong the pre surgical waiting time for critically ill patients, consequently giving a chance of life-saving procedure.

Keywords: Liver Failure, Acute, Liver Transplantation, Mushroom Poisoning

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358