H-Index
38
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
call: +1.631.629.4327
Mon-Fri 10 am - 2 pm EST

Logo

MSMbanner
Medical Science Monitor Basic Research

AmJCaseRep
MedSciTechnol

eISSN: 2329-0358

Recent Developments in Transplantation and Transfusion Medicine

Hisham A. Edinur, Geoffrey K. Chambers, Paul P.J. Dunn

Human Identification Unit, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia

Ann Transplant 2015; 20:424-429

DOI: 10.12659/AOT.894003

Available online: 2015-07-28

Published: 2015-07-28


#894003

ABSTRACT: Transplantation and transfusion are related and clinically important areas of multidisciplinary expertise, including pre-operative treatment, donor recruitment, tissue matching, and post-operative care. We have seen significant developments in these areas, especially in the late 20th and early 21st century. This paper reviews the latest advances in modern transplantation and transfusion medicine, including several new genetic markers (e.g., major histocompatibility complex class I chain-related gene A, killer cell immunoglobulin-like receptor, and human platelet antigens) for donor and recipient matching, genotyping platforms (e.g., next-generation sequencer and Luminex technology), donor recruitment strategies, and several clinical applications in which genotyping has advantages over agglutination tests (e.g., genotyping of weakly expressed antigens and determination of blood groups and human leukocyte antigen types in multi-transfused patients). We also highlight the roles of population studies and international collaborations in moving towards more efficient donor recruitment strategies.

Keywords: Donor Selection, transfusion medicine, Transplantation



Back