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Medical Science Monitor Basic Research


eISSN: 2329-0358

Immunological Risk Factors in Biliary Strictures after Liver Transplantation

Federico Mocchegiani, Paolo Vincenzi, Jacopo Lanari, Roberto Montalti, Daniele Nicolini, Gianluca Svegliati Baroni, Andrea Risaliti, Marco Vivarelli

Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy

Ann Transplant 2015; 20:218-224

DOI: 10.12659/AOT.892393

Available online: 2015-04-20

Published: 2015-04-20


Background: The purpose of this study was to investigate immunological risk factors associated with BS (Biliary Strictures) after LT (Liver Transplantation).
Material and Methods: The study included 192 patients out of 273 adult liver transplantations performed from August 2005 to December 2012, with a radiological or surgically proven biliary stricture. About 35 potential risk factors for biliary strictures were studied.
Results: A biliary stricture was diagnosed in 22.9% of transplants; the anastomotic type and the non-anastomotic type complicated the transplantation in 18.2% and 7.8% of cases, respectively. Six patients (3.1%) presented both of forms. Univariate analysis using logistic regression showed that preoperative serum bilirubin level >2 mg/dl (P=0.040), donor age >46 years old (P=0.007), positive crossmatch (P=0.007), product of donor age and preoperative Model for End Stage Liver Disease (DMELD) >710 (P=0.011), occurrence of acute or chronic rejection (P=0.004; P=0.003), and biliary leak (P=0.002) were all significantly associated with the development of biliary stricture. At the multivariate analysis, Primary Biliary Cirrhosis (PBC) (P=0.019), donor age >46 years (P=0.008), crossmatch positivity (P=0.001), and acute or chronic rejection (P=0.005; P=0.043) appeared to be the only variables independently associated with the development of a biliary stricture.
Conclusions: Immunological risk factors (PBC, crossmatch positivity, acute and chronic rejection) emerged as being the most important variables associated to the development of biliary strictures after LT.

Keywords: Biliary Tract, Graft Rejection, Liver Transplantation, Postoperative Complications, Risk Factors