05 September 2014 : Original article
Injection of G-CSF During Leukaphereses Reduces the Number of Aphereses Needed for Mobilization in Unrelated Hematopoietic Stem Cell Donors
Emilian SnarskiABCDFG, Mikołaj AchremczykDEF, Olga TyrasE, Małgorzata KrólB, Maria KrólB, Elżbieta UrbanowskaB, Tomasz CzerwD, Sebastian GiebelD, Wiesław Wiktor JędrzejczakADOI: 10.12659/AOT.890903
Ann Transplant 2014; 19:444-446
Abstract
BACKGROUND: This is a single-center, retrospective study in the field of mobilization of hematopoietic stem cell from unrelated donors. We aimed to investigate whether delaying the last G-CSF dose after the start of apheresis influences its results.
MATERIAL AND METHODS: The medical records of 55 unrelated hematopoietic stem cell donors during the period 2010–2013 were analysed. In this series, 40 received donors the last G-CSF injection prior to the leukapheresis procedure, and 15 received the last injection after apheresis was initiated.
RESULTS: In the delayed G-CSF application group, more donors had already reached the requested cell number during first apheresis than in the group treated following the standard procedure (73% vs. 35%, respectively; p<0.01). Also, the average total G-CSF dose needed to mobilize the requested cell number was lower (41 µg/kg vs. 48 µg/kg, respectively, p=0.002).
CONCLUSIONS: Delayed G-CSF use in donors undergoing stem cell mobilization shows a better efficiency of stem cell mobilization.
Keywords: Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization, Peripheral Blood Stem Cell Transplantation
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