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Medical Science Monitor Basic Research


eISSN: 2329-0358

The Relationship Between Daily Urinary Sodium Excretion and Metabolic Syndrome in Patients with Kidney Transplantation

Aydin Unal, Ismail Kocyigit, Murat Hahri Sipahioglu, Bulent Tokgoz, Oktay Oymak

Department of Nephrology, Erciyes University Medical School, Kayseri, Turkey

Ann Transplant 2014; 19:397-402

DOI: 10.12659/AOT.890779

Available online: 2014-08-12

Published: 2014-08-12


Background: The aim of this study was to determine whether there is a relationship between daily urinary sodium excretion and metabolic syndrome in kidney transplantation patients.
Material and Methods: This cross-sectional study included 76 adult renal transplantation recipients. To calculate urinary sodium excretion, 24-h urine samples were collected. Metabolic syndrome was diagnosed according to Adult Treatment Panel III (ATP III) criteria updated in a statement from the American Heart Association (AHA)/National Heart, Lung, and Blood Institute (NHLBI) in 2005.
Results: Mean age of the 76 patients was 38±10 years; 21 of the 76 patients were female. Metabolic syndrome was found in 52 (68.4%) of the 76 renal transplantation patients. Mean daily urinary sodium excretion was 190±102 mmol/day, which is equal to a salt intake of 11.1 g/day. Daily urinary sodium excretion was significantly higher in patients with metabolic syndrome compared to those without metabolic syndrome (209±112 mmol/day and 150±62 mmol/day, respectively, p: 0.005). Daily urinary sodium excretion correlated with diastolic blood pressure (r: 0.254, p: 0.028), serum glucose concentration (r: 0.446, p: <0.001), and creatinine clearance (r: 478, p: <0.001). In addition, although there was no significant correlation between daily urinary sodium excretion and systolic blood pressure, the statistical significance was borderline (r: 0.221, p: 0.056).
Conclusions: There is a significant relationship between daily urinary sodium excretion and metabolic syndrome in renal transplant recipients. The Turkish kidney transplantation patients consume a great amount of salt and salt intake is positively correlated with blood pressure.

Keywords: Blood Pressure, Kidney Transplantation, Metabolic Syndrome X