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Medical Science Monitor Basic Research


eISSN: 2329-0358

Guillain-Barré syndrome in the course of EBV infection after kidney transplantation – a case report

Anna Masajtis-Zagajewska, Katarzyna Muras, Alina Mochecka-Thoelke, Ilona Kurnatowska, Michal Nowicki

Ann Transplant 2012; 17(3): 133-137

DOI: 10.12659/AOT.883468

Available online: 2012-09-26

Published: 2012-09-26

Background:    Neurological complications are quite frequent in patients after solid organ transplantation, mostly affecting the central nervous system, and less frequently the peripheral nerves. Guillain-Barré syndrome (GBS), a reactive autoimmune disease of the nervous tissue, is the most common cause of acute polyneuropathy in adults following a viral or bacterial infection. GBS has been also linked to neurotoxic adverse effects of calcineurin inhibitors. This syndrome occurs relatively frequently in patients after bone marrow transplantation, but has been a rare complication in solid organ transplant recipients. Epstein-Barr virus (EBV) infection is relatively common in transplant recipients and in some cases may lead to neurological complications.
    Case Report:    In this report we present an interesting case of a patient who developed GBS in the course of EBV infection 1 year after kidney transplantation.
    Conclusions:    In patients with rapid development of polyneuropathy after transplantation, Guillain-Barré syndrome should be excluded.

Keywords: Guillain-Barre sydrome, EBV infection, Kidney Transplantation