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Medical Science Monitor Basic Research


eISSN: 2329-0358

Indication of liver transplantation for jaundice-free biliary atresia with portal hypertension

Yukihiro Sanada, Koichi Mizuta, Taizen Urahashi, Yoshiyuki Ihara, Taiichi Wakiya, Noriki Okada, Naoya Yamada, Satoshi Egami, Kentaro Ushijima, Shinya Otomo, Koichi Sakamoto, Yoshikazu Yasuda, Hideo Kawarasaki

Ann Transplant 2011; 16(4): 7-11

ID: 882212

Available online:

Published: 2011-12-30


Background:    At the present time, indications of liver transplantation (LT) for jaundice-free biliary atresia (BA) patients include intractable cholangitis, portal hypertension and pulmonary vascular disorders. However, the timing of LT remains unclear. In the current study, we describe the therapeutic strategies for jaundice-free BA patients.
    Material/Methods:    129 BA patients were undergone LDLT between May, 2001 and April, 2010 in the Department of Transplant Surgery, Jichi Medical University, Japan.
    Results:    The indications of LDLT for jaundice-free BA patients was 30 patients (30/129, 23%), and included portal hypertension (16 patients, 53%). Among the 16 patients with portal hypertension, there were 7 patients (7/16, 23%) in which uncontrollable gastrointestinal bleeding was an indication of LDLT. There were 5 patients (5/7; 71%) in which bleeding sites were not identified, and 3 patients (3/7; 43%) in which supportive treatments against collateral vessels were performed as a previous treatment.
    Conclusions:    Even in jaundice-free BA patients, after supportive treatments for portal hypertension are performed, it is necessary to assess the esophageal and gastrointestinal varices regularly and to also prepare for LT simultaneously because there is a probability of the complication of uncontrollable gastrointestinal bleeding.

Keywords: biliary atresia, Jaundice, portal hypertension, uncontrollable gastrointestinal bleeding, Liver Transplantation