Comparison of immediate renal dysfunction in split and partial liver transplantation versus full size liver transplantation in Shiraz transplant centre
Mohammad Mahdi Sagheb, Maryam Sharifian, Saghar Ahmadi, Maryam Moini, Ghanbar-Ali Rais-Jalali, Saeed Behzadi, Jamshid Roozbeh, Hamed Jalaian, Saman Nikeghbalian, Ali Bahador, Heshmatolah Salahi, Mehdi Salehipoor, Koroush Kazemi, Seyed Ali Malek-Hosseini
Ann Transplant 2011; 16(2): 36-42
Background: Renal dysfunction (RD) is a common complication following liver transplantation. Postoperative renal function after split liver transplant (SLT) and (partial living related liver transplant) (LRLT) has not been well studied yet.
Material/Methods: Renal function immediately after surgery was analyzed retrospectively in 32 patients that received SLT and LRLT. Serum creatinine (SCr) was measured before surgery, and, after transplantation daily during the first week and at 14, 21, and 28 days after transplantation. Patient’s medical records were reviewed to find clinical data;Model for end-stage liver disease (MELD) score, Child-Turcotte-Pugh score (CTP) class, the length of surgery, length of anhepatic phase, hospital and ICU admission, incidence of acute rejection, renal dysfunction, and sepsis. These data compared between groups.
Results: Length of surgery and anhepatic phase was longer in SLT and LRLT group (P<0.05). The incidence of acute rejection, reoperation, and complication such as sepsis was higher in SLT and LRLT group than FSLT group (P<0.05). There were no significant difference between groups with respect to MELD, CTP score, the need for transfusions, the length of admission to the hospital and ICU. Immunosuppression regimens were similar in both groups. RD developed in 25.8% of SLT and LRLT patients, but in only 9.5% of FSLT patients (p=0.063). The requirement for RRT in SLT and LRLT group (12.5%) was greater than that in the FSLT group (2.3%); P=0.20.
Conclusions: Although the number of patients studied was small, our data suggests a higher incidence of RD in patients receiving SLT and LRLT.
Keywords: Liver Transplantation, renal dysfunction, partial