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30 June 2011

Comparison of immediate renal dysfunction in split and partial liver transplantation versus full size liver transplantation in Shiraz transplant centre

Mohammad Mahdi SaghebAEF, Maryam SharifianABEF, Saghar AhmadiBC, Maryam MoiniAEF, Ghanbar-Ali Rais-JalaliAEF, Saeed BehzadiAEF, Jamshid RoozbehAEF, Hamed JalaianCD, Saman NikeghbalianAEF, Ali BahadorACE, Heshmatolah SalahiADE, Mehdi SalehipoorABCF, Koroush KazemiACD, Seyed Ali Malek-HosseiniA

Ann Transplant 2011; 16(2): 36-42 :: ID: 881863

Abstract

Background: Renal dysfunction (RD) is a common complication following liver transplantation. Postoperative renal function after split liver transplant (SLT) and (partial living related liver transplant) (LRLT) has not been well studied yet.
Material/Methods: Renal function immediately after surgery was analyzed retrospectively in 32 patients that received SLT and LRLT. Serum creatinine (SCr) was measured before surgery, and, after transplantation daily during the first week and at 14, 21, and 28 days after transplantation. Patient’s medical records were reviewed to find clinical data;Model for end-stage liver disease (MELD) score, Child-Turcotte-Pugh score (CTP) class, the length of surgery, length of anhepatic phase, hospital and ICU admission, incidence of acute rejection, renal dysfunction, and sepsis. These data compared between groups.
Results: Length of surgery and anhepatic phase was longer in SLT and LRLT group (P<0.05). The incidence of acute rejection, reoperation, and complication such as sepsis was higher in SLT and LRLT group than FSLT group (P<0.05). There were no significant difference between groups with respect to MELD, CTP score, the need for transfusions, the length of admission to the hospital and ICU. Immunosuppression regimens were similar in both groups. RD developed in 25.8% of SLT and LRLT patients, but in only 9.5% of FSLT patients (p=0.063). The requirement for RRT in SLT and LRLT group (12.5%) was greater than that in the FSLT group (2.3%); P=0.20.
Conclusions: Although the number of patients studied was small, our data suggests a higher incidence of RD in patients receiving SLT and LRLT.

Keywords: Liver Transplantation, renal dysfunction, partial

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358