21 May 2009
Analysis of risk factors influencing acute graft rejection in allograft recipients
P Jurkowski, A Mikłaszewicz, M Cićkiewicz, P Orszulak, M Fiedor, Z Lewandowski, P FiedorAnn Transplant 2009; 14(1): 76-76 :: ID: 880480
Abstract
Background: Stability of graft function after allotransplantation is difficult to maintain. There are many factors that can worsen recipient's condition and may lead to acute graft rejection. The aim of this study was to evaluate the influence of various factors on the incidence of acute graft rejection episodes in patients after liver and kidney allotransplantation.
Material/Methods: 171 recipients after kidney and liver transplantation were
analyzed. Factors of interest included: immunosuppression patterns, existence of diabetes, received induction therapy, warm and cold ischemia time and acute rejection time. Next, the data of donors for the 171 patients was collected. All data was statistically analyzed.
Results: The number of kidney and liver recipients without acute graft rejection was the lowest for CsA and CellCept model compared to the highest for CsA and Aza model (p=0.0008). Tacrolimus causes the highest risk of induced diabetes after transplantation (p<0.001). The number of kidney and liver recipients with acute graft rejection was higher in patients who received graft from females comparing with the group who received grafts from males (p=0.0282). Every minute of warm ischemia time increases the risk of acute
graft rejection by 12.7%. The percentage of patients without AGR after 7 months with 2 common alleles, 1 common allele and 0 common alleles in HLA-DR was 100%, 55% and 30% respectively (p=0.0128).
Conclusions: The acute rejection time depends on many factors and how they affect graft stability was elucidated in this study.
Keywords: Immunosuppression, Kidney Transplantation, Liver Transplantation
In Press
06 May 2022 : Original article
Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...Ann Transplant In Press; DOI: 10.12659/AOT.936293
27 Apr 2022 : Review article
A Systematic Review of the Literature on Chronic Kidney Disease Following Liver TransplantationAnn Transplant In Press; DOI: 10.12659/AOT.935170
Most Viewed Current Articles
31 Dec 1969 : Original article
Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...DOI :10.12659/AOT.933588
Ann Transplant 2021; 26:e933588
31 Dec 1969 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive ModelsDOI :10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
31 Dec 1969 : Review article
Kidney Transplantation in the Times of COVID-19 – A Literature ReviewDOI :10.12659/AOT.925755
Ann Transplant 2020; 25:e925755
31 Dec 1969 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860