Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Memory and executive functions in patients after transplantation treated with different immunosuppressive drugs

L Gawryś, G Senatorski, L Pączek, L Kaczmarek

Ann Transplant 2009; 14(1): 75-75 :: ID: 880475

Abstract

Background: Rapamycin (Sirolimus) is an immunosuppressive drug used in
pharmacotherapy of patients after transplantation. The aim of the study was to investigate memory of patients after transplantation, which undergo the immunosuppressive pharmacotherapy with rapamycin. Rapamycin inhibits mTOR protein kinase, which is one of the key regulators of translational capacity. It was repeatedly shown that mTOR kinase is involved in synaptic plasticity mechanisms and long term memory formation.
Material/Methods: This study examined memory functions in three groups of patients after transplantation taking different immunosuppressive drugs: rapamycin (n=18), cyclosporine (n=15), mycophenolate mofetil (n=18) and group of 19 control subjects. Two procedural (Mirror Reading and Serial Reaction Task) and one declarative task (Auditory Verbal Learning Test) were employed in order to measure acquisition and retention of information. Since memory performance may be reduced owing to executive dysfunction, four measures of cognitive control were included in the study: Trial Making Test, Stroop Test, Wisconsin Card Sorting Test and Digit Span.
Results: The performance of memory tasks and tests of executive function did not differ in the three patients groups and there was no effect of immunosuppressive treatment used. No decrease of memory and executive function was found in patients after transplantation in comparison with the
healthy control subjects.
Conclusions: Immunosuppressive therapy had no effect on cognitive functions in studied patients group.

Keywords: Immunosuppression

Comments

In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

Most Viewed Current Articles

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

24 Jul 2020 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358