Memory and executive functions in patients after transplantation treated with different immunosuppressive drugs
L Gawryś, G Senatorski, L Pączek, L Kaczmarek
Ann Transplant 2009; 14(1): 75-75
Available online: 2009-05-21
Background: Rapamycin (Sirolimus) is an immunosuppressive drug used in
pharmacotherapy of patients after transplantation. The aim of the study was to investigate memory of patients after transplantation, which undergo the immunosuppressive pharmacotherapy with rapamycin. Rapamycin inhibits mTOR protein kinase, which is one of the key regulators of translational capacity. It was repeatedly shown that mTOR kinase is involved in synaptic plasticity mechanisms and long term memory formation.
Material/Methods: This study examined memory functions in three groups of patients after transplantation taking different immunosuppressive drugs: rapamycin (n=18), cyclosporine (n=15), mycophenolate mofetil (n=18) and group of 19 control subjects. Two procedural (Mirror Reading and Serial Reaction Task) and one declarative task (Auditory Verbal Learning Test) were employed in order to measure acquisition and retention of information. Since memory performance may be reduced owing to executive dysfunction, four measures of cognitive control were included in the study: Trial Making Test, Stroop Test, Wisconsin Card Sorting Test and Digit Span.
Results: The performance of memory tasks and tests of executive function did not differ in the three patients groups and there was no effect of immunosuppressive treatment used. No decrease of memory and executive function was found in patients after transplantation in comparison with the
healthy control subjects.
Conclusions: Immunosuppressive therapy had no effect on cognitive functions in studied patients group.