Frequency of bacterial infections in diabetic patients treated with simultaneous pancreas-kidney transplantation

Retrospective analysis of pathogens responsible for bacterial infections in
simultaneous pancreas-kidney recipients at various periods of time after
transplantation.
Material/Methods: 40 SPKTx patients were analyzed. Allograft transplantations were performed between 1992 and 2005. The clinical materials were: urine, blood, drains and swabs from different body sites, if signs and symptoms of infection were observed. All microbiological examinations were performed according to the routine procedures.
Results: Bacterial infections in the early period after transplantation (until 1 month) were observed in 19 patients. Most of them were urinary tract infections (UTIs) - 14 cases. The other cases were: wound infections - 4, bacteraemia - 2, peritonitis - 1, pancreatic fistula - 1, abscess of the pancreatic area - 1. In the medium period (2 to 6 months) infections occurred in 10 patients. Among this group UTIs were diagnosed in 8 patients, sepsis in 1 patient and infected diabetic foot in 1 patient. In the late period (from 7[sup]th[/sup] month) infections occurred in 12 patients and they were: UTIs - 10 cases, urosepsis - 2, bacteraemia - 1, purulent salpingo-oophoritis - 1, phlegmonous foot infection - 1, peritoneal abscess - 1.
Conclusions: 1. Diabetic Pts treated with SPKTx in the early period after
transplantation show Gram-positive bacteria infections. They were significant cause of infections when comparing both subsequent periods. 2. In the medium and late period Gram-negative bacteria were the predominant aetiological agents of infections in allograft recipients. 3. It was observed that there were multidrugresistant hospital pathogens among bacteria responsible for infections in the early period after transplantation.

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