Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

The influence of chronic heart failure on pulmonary function tests in patients undergoing orthotopic heart transplantation

M Lizak, M Zakliczyński, A Jarosz, M Zembala

Ann Transplant 2009; 14(1): 66-67 :: ID: 880443

Abstract

Background: Chronic heart failure and airway's obstruction have overlapping syndromes. World criteria for diagnosing and grading of airway's obstruction are based on spirometry results, but may be inadequate when cardiac failure coexists. Cardiac component of pulmonary function tests' (PFT) results can be measured in patients undergoing orthotopic heart transplantation (OHT).
Material/Methods: In 29 patients PFT were performed according to the Polish Phtisiopulmonology Society guidelines before and one year after OHT in the years 2006-2008. Willcoxon matched pairs' tests were used for analysis in Statistica 7.1. General group characteristics included age, sex, NYHA, CCS, BMI, present medication, blood tests and chemistry, exercise test, right heart catheterisation and echocardiography results.
Results: One year after OHT significant improvement in forced expiratory volume in the first second (FEV1) and its percent of predicted value (FEV1%), forced vital capacity (FVC), FVC%, vital capacity (VC) and VC% was observed (accordingly: 2.56 vs. 2.96l, 82 vs. 93%, 3.30 vs. 3.81l, 85 vs. 97%, 3.38 vs. 4.04l, 85 vs. 100%, p<0.01). FEV1 and FVC increment exceeded the cut-off point of 12% of normal value (accordingly: 0.38 and 0.47l) established as spirometry criterion for obstruction reversibility. Elimination of the heart failure by OHT did not result in signifi cant changes in FEV1 to FVC ratio (FEV1%FVC) used as main diagnostic criterion of chronic obstructive lung disease.
Conclusions: Chronic heart failure contributes to FEV1 variability of 0.4l or 12.6% of normal value which limits the usefulness of PFT in diagnosing and grading of airway obstruction in this group. Induction of inhaled betamimetics and steroids should be carefully considered and symptom-based in this group of patients since optimalisation of CHF treatment can be the best way to improve spirometry results. FEV1%FVC seems independent of concomitant heart function impairment.

Keywords: Heart Transplantation, clinical outcome

Comments

In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

27 Apr 2022 : Review article  

A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation

Ann Transplant In Press; DOI: 10.12659/AOT.935170  

Most Viewed Current Articles

31 Dec 1969 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

31 Dec 1969 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

31 Dec 1969 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

31 Dec 1969 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358