21 May 2009
Prevalence of chronic kidney disease is extremely high in heart transplant recipients
P Przybylowski, J MałyszkoAnn Transplant 2009; 14(1): 66-66 :: ID: 880440
Abstract
Background: Patients with cardiovascular diseases often show signs of renal dysfunction due to concomitant diabetes, hypertension, and congestive heart failure. Studies have shown that GFR (glomerular filtration rate) less than 60 ml/min is a forerunner of premature cardiovascular death. The aim of the study was to assess the prevalence of kidney dysfunction in heart transplant recipients using estimated GFR according to simplified MDRD, Cockcroft-Gault or creatinine clearance (24 hours urine collection) in a cohort of 162 consecutive patients.
Results: Normal serum creatinine was observed in 46% patients. Mean GFR was 62.92±31.04 ml/min (Cockcroft-Gault formula), 55.38±26.74 ml/min (MDRD) and 62.62±35.61 ml/min (creatinine clearance). According to Cockcroft-Gault formula stage 2 CKD i.e.GFR 60-89 ml/min was diagnosed in 92 patients (56.8%), and stage 3 CKD i.e. GFR 30-59ml/min was diagnosed in 62 patients (38.3%) and stage 4 CKD i.e. GFR 15-29ml/min was diagnosed in 14 patients (8.6%). According to MDRD formula stage 2 CKD was found in 157 patients (96.9%), stage 3 CKD was found in 105 patients (64.8%) and stage 4 in 28 (17.3%) patients. According to creatinine clearance stage 2 CKD was found in 145 patients (89.5%), stage 3 CKD was found in 135 patients (83.3%) and stage 4 was found in 21 (13.0%) patients. Clinically significant CKD (GFR<60ml/min) was found in 38.3%-83.3% depending on the formula used to estimate GFR or creatinine clearance.
Conclusions: The prevalence of CKD is extremely high in heart transplant recipients. Evaluation of renal function is important in order to select the appropriate strategy to reduce the cardiovascular risk.
Keywords: Heart Transplantation, Immunosuppression
In Press
08 Mar 2024 : Original article
Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...Ann Transplant In Press; DOI: 10.12659/AOT.943532
14 Mar 2024 : Original article
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort StudyAnn Transplant In Press; DOI: 10.12659/AOT.943652
14 Mar 2024 : Case report
Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...Ann Transplant In Press; DOI: 10.12659/AOT.942358
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860