21 May 2009
Myocardial blush grade (mbg) is not altered by microvasculopathy or acute rejection (ar) occurring early after orthotopic heart transplantation (OHT)
M Zakliczyński, A Lekston, D Konecka-Mrówka, J Nożyński, D Trybunia, Ł Pyka, M Świerad, R Przybylski, M ZembalaAnn Transplant 2009; 14(1): 65-65 :: ID: 880438
Abstract
Background: A relation between microvasculopathy observed in endomyocardial biopsies (EMBs) and clinical coronary vasculopathy (CAV) after OHT remains controversial. Aim of the study was to find a potential relation between microvasculopathy features and AR observed early after OHT and MBG.
Material/Methods: We performed a retrospective analysis of early coronary
angiographies (performed between 4th and 6th week after OHT) from 55 subjects. Based on MBG analysis we identifi ed a group of six pts. with decreased MBG (6M, 52±7y/o, ischemic c-pathy in 50%), that was confronted with a group of 49 pts. with normal MBG (43M/6F, 45±12y/o, ischemic c-pathy in 39%). Microvasculopathy was assessed using the following features: presence of prominent endothelial cells, degeneration of the endothelium, thickening of the muscle layer, thickening of the vascular wall (basal membrane and muscle layer), presence of lymphocytes in the arteriolar wall with-out any other signs of rejection vasculitis, periarteriolar fibrosis, and an occluded arteriolar lumen.
Results: Significant AR was observed in 17 vs. 10% of pts. with decreased and normal MBG, respectively. All microvasculopathy features, except presence of prominent endothelial cells and periarteriolar fibrosis, were more frequent in pts. with normal MBG. None of the differences was statistically significant.
Conclusions: MBG is not influenced by AR or microvasculopathy features observed early after OHT.
Keywords: Heart Transplantation
In Press
06 May 2022 : Original article
Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...Ann Transplant In Press; DOI: 10.12659/AOT.936293
27 Apr 2022 : Review article
A Systematic Review of the Literature on Chronic Kidney Disease Following Liver TransplantationAnn Transplant In Press; DOI: 10.12659/AOT.935170
Most Viewed Current Articles
31 Dec 1969 : Original article
Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...DOI :10.12659/AOT.933588
Ann Transplant 2021; 26:e933588
31 Dec 1969 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive ModelsDOI :10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
31 Dec 1969 : Review article
Kidney Transplantation in the Times of COVID-19 – A Literature ReviewDOI :10.12659/AOT.925755
Ann Transplant 2020; 25:e925755
31 Dec 1969 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860