Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Mixed (cellular and humoral) acute rejection in elective biopsies received from the heart transplant recipients

S Zeglen, J Nozynski, E Wozniak-Grygiel, M Zakliczynski, A Laszewska, J Wojarski, R Wojnicz, R Przybylski, M Zembala

Ann Transplant 2009; 14(1): 63-63 :: ID: 880428


Background: Acute cellular heart transplant rejection is characterized by active lymphocytic infi ltration, whereas the humoral response presents the complement deposits in myocardial tissue. These two processes may be responsible for hemodynamic compromise in the first months after heart transplantation, when cellular rejection becomes faster and more severe than humoral rejection. The specific character of the first biopsy, because of the summarized nociceptive factors (e.g. rejection, warm ischemia, transportation time) should be pointed out. The aim of the study was to estimate the coexistence of humoral rejection in the first post-transplant biopsy with moderate cellular rejection, as an additional prognostic factor.
Material/Methods: A part of the first post-transplant endomyocardial biopsy
material was collected in a tissue freezing medium, whereas the remaining part was used for routine histology studies. The studied group included 13 biopsies (obtained from 11 men and 2 women; mean age 52.6±5.3 yr) with verified ISHLT mild/moderate rejection grade, whereas control group consisted of 11 biopsies (obtained from 8 men and 3 women; mean age 54.8±3.6 yr) with no signs of rejection. The complement deposits were determined immunohistochemically using anti-C4d antibodies (Quidel Corporation).
Results: None of the control group cases showed positive reaction, whereas in the studied group in 3 cases (3 men; 56.1±5.8 yr) the cellular infiltrates joined with regional positive anti-C4d expression. This expression occurred in all myocardial components adjacent to lymphocytic infiltrations. Survival rate was comparable in both clear cellular and mixed rejections. Relative rate of grade 3 rejection in post-transplant period was increased in patients with mixed rejection.
Conclusions: The term "mixed acute rejection" should be applied for such cases, when there is coincidence of the two forms of acute rejection and it seems to be associated with more frequent grade 3 rejection in the long term follow up.

Keywords: Heart Transplantation


In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

27 Apr 2022 : Review article  

A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation

Ann Transplant In Press; DOI: 10.12659/AOT.935170  

Most Viewed Current Articles

31 Dec 1969 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

31 Dec 1969 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

31 Dec 1969 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

31 Dec 1969 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358