21 May 2009
Advanced glycation end-products (ages) in transplanted heart pathology of patients with or without diabetes mellitus type 2 (DM)
M Zakliczyński, J Nożyński, D Konecka-Mrówka, B Nikiel, J Młynarczyk-Liszka, D Lange, M ZembalaAnn Transplant 2009; 14(1): 62-62 :: ID: 880423
Abstract
Background: Abnormal glycaemia in orthotopic heart transplant (OHT)
recipients may result in AGEs formation. However the role of AGEs in development of acute rejection (AR) and coronary vasculopathy (CAV) is unknown. The Aim of the study was to localize AGEs in endomyocardial biopsies (EMBs) in order to correlate their presence with AR and CAV in OHT
subjects with and without DM.
Material/Methods: Elective EMBs performed 3y post OHT in 65 pts. with DM (60M/5F, 49±8y/o) and 24pts. without DM (21M/3F, 42±10y/o) were involved in the study. Localization of AGEs in myocardial paraffin sections was assessed immunochemically using mouse monoclonal anti-AGE antibodies. The presence of AGEs in cardiomyocytes, stromal cells, connective tissue cells and capillaries was described with semi-quantitative scale.
Results: Occurrence of AGEs was similar in both groups - cardiocytes 74 vs.
63%, stroma 34 vs. 33%, connective tissue 14 vs. 9%, and capillaries 32vs.33% - in DM vs. non-DM pts., while intensity of staining was significantly higher in DM subjects. Overall number of AR episodes and mean EMB score were significantly correlated with AGE presence in cardiomyocytes (r=0.31/0.25, p=0.011/0.049, Spearman test), but only in DM group. There was no relation between AGEs and CAV in DM pts., while time free from any angiographically confirmed CAV, and CAV related event was significantly longer in non-DM pts. with AGEs in cardiomyocytes and/or capillaries (p=0.017/0.014/0.03/0.014 respectively, log-rank test).
Conclusions: AGEs occurrence in DM subjects is related to AR, but does not predict CAV, while in non-DM patients it is correlated with AR, but prolongs freedom from CAV.
Keywords: Heart Transplantation
In Press
18 Mar 2024 : Original article
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of R...Ann Transplant In Press; DOI: 10.12659/AOT.943282
20 Mar 2024 : Original article
Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single InstitutionAnn Transplant In Press; DOI: 10.12659/AOT.942252
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
02 Apr 2024 : Original article
Liver Transplantation from Brain-Dead Donors with Hepatitis B or C in South Korea: A 2014-2020 Korean Organ...Ann Transplant In Press; DOI: 10.12659/AOT.943588
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860