Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Pentoxifylline augments fasting induced nephroprotection in ischemic model of acute kidney injury in rats

A Wystrychowski, W Wystrychowski, P Król, E Obuchowicz, L Cierpka, A Więcek

Ann Transplant 2009; 14(1): 60-60 :: ID: 880418

Abstract

Background: Ischemic acute kidney injury (iAKI) activates also general inflammatory reaction. Prolonged fasting exerts anti-inflammatory effects through increased secretion of ghrelin - an orexigenic hormone produced in the gastrointestinal system that inhibits NF-B activation and induces IL-10 release. PTX has similar immunomodulating and anti-inflammatory properties. The aim of this study was to assess and compare the influence of feeding status and PTX administration on the course of iAKI.
Material/Methods: 44 male Sprague-Dawley rats, 14 days after right nephrectomy and 7 days before renal ischemia were placed in individual cages preventing feaces consumption with ad libitum water access. Rats of groups Ia and Ib were fed with no limitations as opposed to groups IIa and IIb, starved for 32 hours prior to renal ischemia. 90 min before left kidney vascular pedicle clamping (for 45 min) rats of groups Ib/IIb and Ia/IIa were given PTX (100 mg/kg body weight in 1ml 0.9% NaCl, s.c.) or 0.9% NaCl only, respectively. Creatinine clearance (CrCl; ml/min/kg bw), fractional excretion of sodium (FENa; %) and proteinuria to creatinine clearance ratio (PUrea/ClCrea) were estimated 24 hours after ischemia.
Results: As shown in the table, both fasting and PTX administration diminished the degree of ischemia-induced impairment of renal function. Their combined effects were additive.
Conclusions: Fasting and treatment with pentoxifylline in the periischemic period exert additive nephroprotective effects in the setting of ischemic acute kidney injury. These findings may be useful in the studies and future practice of preservation of kidney transplant function.

Keywords: Ischemia reperfusion injury, Kidney Transplantation

Add Comment 0 Comments

In Press

08 Mar 2024 : Original article  

Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...

Ann Transplant In Press; DOI: 10.12659/AOT.943532  

14 Mar 2024 : Original article  

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study

Ann Transplant In Press; DOI: 10.12659/AOT.943652  

14 Mar 2024 : Case report  

Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...

Ann Transplant In Press; DOI: 10.12659/AOT.942358  

15 Mar 2024 : Review article  

Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...

Ann Transplant In Press; DOI: 10.12659/AOT.941185  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358